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butizide

Product Name
butizide
CAS No.
2043-38-1
Chemical Name
butizide
Synonyms
S-3500;Su-6187;Butizid;Modenol;Saltucin;butizide;Eunephran;Butizidum;Buthiazide;Thiabutazide
CBNumber
CB2875097
Molecular Formula
C11H16ClN3O4S2
Formula Weight
353.85
MOL File
2043-38-1.mol
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butizide Property

Melting point:
214-217°C
Boiling point:
562.7±60.0 °C(Predicted)
Density 
1.4221 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.01±0.40(Predicted)
color 
White to Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
263352
Product name
Buthiazide
Packaging
25mg
Price
$355
Updated
2021/12/16
TRC
Product number
B690035
Product name
Buthiazide
Packaging
2.5g
Price
$1355
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010900
Product name
BUTHIAZIDE
Purity
95.00%
Packaging
2.5G
Price
$1947
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB19384
Product name
Buthiazide
Packaging
500mg
Price
$210
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010900
Product name
BUTHIAZIDE
Purity
95.00%
Packaging
250MG
Price
$315
Updated
2021/12/16
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butizide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Saltucin,Boehringer Mannheim,W. Germany,1961

Uses

Diuretic and antihypertensive.

Definition

ChEBI: Butizide is a benzothiadiazine.

Manufacturing Process

Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.

Therapeutic Function

Diuretic, Antihypertensive

butizide Preparation Products And Raw materials

Raw materials

Preparation Products

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butizide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1958
Advantage
55
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
3519
Advantage
58
Suzhou Laihui Biotechnology Co., Ltd.
Tel
180-13160973 +86-18013160973
Fax
0512-68236973
Email
rywaybio@gmail.com
Country
China
ProdList
299
Advantage
55
Jinan Guoding Pharmaceutical Technology Co., Ltd.
Tel
15665775653
Fax
053167801621
Email
sales@guodingpharma.com
Country
China
ProdList
493
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55477
Advantage
58
Hangzhou Molot Chemical Technology Co., Ltd.
Tel
0571-56906266 17706505167
Email
sales@morotchem.com
Country
China
ProdList
500
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8618
Advantage
58

2043-38-1, butizideRelated Search:


  • 6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • butizide
  • Buthiazide
  • Thiabutazide
  • Eunephran
  • S-3500
  • Saltucin
  • Su-6187
  • 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-chloro-3-isobutyl-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • 6-Chloro-3,4-dihydro-3-(2-Methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide
  • Butizid
  • Isobutylhydrochlorothiazide
  • Modenol
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(2-methylpropyl)-, 1,1-dioxide
  • Butizidum
  • 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λsup6sup,2,4-benzothiadiazine-7-sulfonamide
  • 2043-38-1
  • C11H16ClN3O4S2
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds