ChemicalBook > CAS DataBase List > butizide
butizide
- Product Name
- butizide
- CAS No.
- 2043-38-1
- Chemical Name
- butizide
- Synonyms
- S-3500;Su-6187;Butizid;Modenol;Saltucin;butizide;Eunephran;Butizidum;Buthiazide;Thiabutazide
- CBNumber
- CB2875097
- Molecular Formula
- C11H16ClN3O4S2
- Formula Weight
- 353.85
- MOL File
- 2043-38-1.mol
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butizide Property
- Melting point:
- 214-217°C
- Boiling point:
- 562.7±60.0 °C(Predicted)
- Density
- 1.4221 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.01±0.40(Predicted)
- color
- White to Yellow
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N-Bromosuccinimide Price
Usbiological
- Product number
- 263352
- Product name
- Buthiazide
- Packaging
- 25mg
- Price
- $355
- Updated
- 2021/12/16
TRC
- Product number
- B690035
- Product name
- Buthiazide
- Packaging
- 2.5g
- Price
- $1355
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB19384
- Product name
- Buthiazide
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB19384
- Product name
- Buthiazide
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
AK Scientific
- Product number
- 1427CA
- Product name
- Butizide
- Packaging
- 100mg
- Price
- $164
- Updated
- 2021/12/16
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butizide Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Originator
Saltucin,Boehringer Mannheim,W. Germany,1961
Uses
Diuretic and antihypertensive.
Definition
ChEBI: Butizide is a benzothiadiazine.
Manufacturing Process
Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C.
Therapeutic Function
Diuretic, Antihypertensive
butizide Preparation Products And Raw materials
Raw materials
Preparation Products
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