butizide

Product Name: butizide
CAS No.: 2043-38-1
Chemical Name: butizide
Synonyms: S-3500;Su-6187;Butizid;Modenol;Saltucin;butizide;Eunephran;Butizidum;Buthiazide;Thiabutazide
CBNumber: CB2875097
Molecular Formula: C11H16ClN3O4S2
Formula Weight: 353.85
MOL File: 2043-38-1.mol

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butizide Property

Melting point:: 214-217°C
Boiling point:: 562.7±60.0 °C(Predicted)
Density: 1.4221 (rough estimate)
refractive index: 1.6100 (estimate)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.01±0.40(Predicted)
color: White to Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 263352
Product name: Buthiazide
Packaging: 25mg
Price: $355
Updated: 2021/12/16

TRC

Product number: B690035
Product name: Buthiazide
Packaging: 2.5g
Price: $1355
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010900
Product name: BUTHIAZIDE
Purity: 95.00%
Packaging: 2.5G
Price: $1947
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19384
Product name: Buthiazide
Packaging: 500mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010900
Product name: BUTHIAZIDE
Purity: 95.00%
Packaging: 250MG
Price: $315
Updated: 2021/12/16

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butizide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Saltucin,Boehringer Mannheim,W. Germany,1961

Uses

Diuretic and antihypertensive.

Definition

ChEBI: Butizide is a benzothiadiazine.

Manufacturing Process

Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.

Therapeutic Function

Diuretic, Antihypertensive

butizide Preparation Products And Raw materials

Raw materials

Preparation Products

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butizide Suppliers

Canada 1 China 29 South Korea 1 United Kingdom 1 United States 4 Global 36

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2043-38-1, butizideRelated Search:

Propantheline bromide mebutizide butizide CYCLOTHIAZIDE Cyclopenthiazide 2-AMINO-N-BUTYLBENZENESULFONAMIDE Hydrochlorothiazide ethiazide 2-amino-N-propylbenzenesulfonamide

6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide

butizide

Buthiazide

Thiabutazide

Eunephran

S-3500

Saltucin

Su-6187

6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

6-chloro-3-isobutyl-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

6-Chloro-3,4-dihydro-3-(2-Methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide

Butizid

Isobutylhydrochlorothiazide

Modenol

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(2-methylpropyl)-, 1,1-dioxide

Butizidum

6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λsup6sup,2,4-benzothiadiazine-7-sulfonamide

2043-38-1

C11H16ClN3O4S2

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds