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Cyclopenthiazide

Product Name
Cyclopenthiazide
CAS No.
742-20-1
Chemical Name
Cyclopenthiazide
Synonyms
su8341;salimid;salimed;navidrix;NAVIDREX;Navidreks;NSC 107679;Salurilo-C;Ciba 8341-Su;Ultra-Minzil
CBNumber
CB1295254
Molecular Formula
C13H18ClN3O4S2
Formula Weight
379.88
MOL File
742-20-1.mol
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Cyclopenthiazide Property

Melting point:
230°
Boiling point:
605.6±65.0 °C(Predicted)
Density 
1.3650 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Refrigerator
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly)
form 
Solid
pka
9.00±0.40(Predicted)
color 
White to Off-White
Water Solubility 
50mg/L(room temperature)
CAS DataBase Reference
742-20-1(CAS DataBase Reference)
EPA Substance Registry System
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1)
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Safety

Toxicity
LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C988420
Product name
Cyclopenthiazide
Packaging
25mg
Price
$185
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005912
Product name
CYCLOPENTHIAZIDE
Purity
95.00%
Packaging
10MG
Price
$255.15
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC146926
Product name
Cyclopenthiazide
Packaging
10mg
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC146926
Product name
Cyclopenthiazide
Packaging
25mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC146926
Product name
Cyclopenthiazide
Packaging
50mg
Price
$550
Updated
2021/12/16
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Cyclopenthiazide Chemical Properties,Usage,Production

Uses

Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.

Uses

Antihypertensive;Sodium Chloride Symporter Inhibitor

Definition

ChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.

World Health Organization (WHO)

Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.

Clinical Use

Thiazide diuretic:
Hypertension

Heart failure

Oedema

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised.
Antibacterials: avoid administration with lymecycline.
Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics.
Antiepileptics: increased risk of hyponatraemia with carbamazepine.
Antifungals: increased risk of hypokalaemia with amphotericin.
Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia occurs.
Ciclosporin: increased risk of nephrotoxicity and possibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias due to hypokalaemia with arsenic trioxide; increased risk of nephrotoxicity and ototoxicity with platinum compounds.
Lithium: excretion reduced, increased toxicity

Metabolism

Cyclopenthiazide appears to be entirely excreted unchanged in the urine.

Cyclopenthiazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclopenthiazide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
ATK CHEMICAL COMPANY LIMITED
Tel
3429815786 13301662590
Fax
+86-21-51619052
Email
sales@atkchemical.com
Country
China
ProdList
7519
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
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View Lastest Price from Cyclopenthiazide manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Cyclopenthiazide 742-20-1
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
Anhui Ruihan Technology Co., Ltd
Product
Cyclopenthiazide 742-20-1
Price
US $80.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000tons
Release date
2023-09-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cyclopenthiazide 742-20-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

742-20-1, CyclopenthiazideRelated Search:


  • 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(cyclopentylmethyl)-3,4-dih
  • 3-cyclopentylmethylhydrochlorothiazidederiv
  • cyclomethiazide
  • navidrix
  • salimed
  • salimid
  • su8341
  • tsiklometiazid
  • ydro-,1,1-dioxide
  • CYCLOPENTHIAZIDE
  • Cyclopentiazide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (6CI, 8CI, 9CI)
  • 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-7-sulfamyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-3-cyclopentylmethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • Ciba 8341-Su
  • Cyclometiazid
  • Cyclopentiazid
  • Navidreks
  • NSC 107679
  • Salurilo-C
  • Ultra-Minzil
  • NAVIDREX
  • 6-chloro-3-cyclopentylmethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • 6-Chloro-3-[cyclopentylmethyl]-3,4-dihydro-[2H]-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
  • 6-Chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
  • Cyclopenthiazide USP/EP/BP
  • HYDROALAZINE HCL
  • 6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
  • Cyclopenthiazide Powder USP Standard
  • cyclopenthiazideis6-chloro-3-cyclopentylmethyl-3,4-dihydro-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide.itcontainsnotlessthan98.0%andnotmorethan102.0%ofc13h18clN3O4S2,calculatedwithreferencetothedriedsubstance
  • 742-20-1
  • C13H18ClN3O4S2
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