Cyclopenthiazide
- Product Name
- Cyclopenthiazide
- CAS No.
- 742-20-1
- Chemical Name
- Cyclopenthiazide
- Synonyms
- su8341;salimid;salimed;navidrix;NAVIDREX;Navidreks;NSC 107679;Salurilo-C;Ciba 8341-Su;Ultra-Minzil
- CBNumber
- CB1295254
- Molecular Formula
- C13H18ClN3O4S2
- Formula Weight
- 379.88
- MOL File
- 742-20-1.mol
Cyclopenthiazide Property
- Melting point:
- 230°
- Boiling point:
- 605.6±65.0 °C(Predicted)
- Density
- 1.3650 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Refrigerator
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 9.00±0.40(Predicted)
- color
- White to Off-White
- Water Solubility
- 50mg/L(room temperature)
- CAS DataBase Reference
- 742-20-1(CAS DataBase Reference)
- EPA Substance Registry System
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1)
Safety
- Toxicity
- LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C988420
- Product name
- Cyclopenthiazide
- Packaging
- 25mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- API0005912
- Product name
- CYCLOPENTHIAZIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $255.15
- Updated
- 2021/12/16
- Product number
- FC146926
- Product name
- Cyclopenthiazide
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC146926
- Product name
- Cyclopenthiazide
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FC146926
- Product name
- Cyclopenthiazide
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
Cyclopenthiazide Chemical Properties,Usage,Production
Uses
Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
Uses
Antihypertensive;Sodium Chloride Symporter Inhibitor
Definition
ChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.
World Health Organization (WHO)
Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.
Clinical Use
Thiazide diuretic:
Hypertension
Heart failure
Oedema
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with
NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased
cardiac toxicity; effects of lidocaine and mexiletine
antagonised.
Antibacterials: avoid administration with
lymecycline.
Antidepressants: increased risk of hypokalaemia
with reboxetine; enhanced hypotensive effect with
MAOIs; increased risk of postural hypotension with
tricyclics.
Antiepileptics: increased risk of hyponatraemia with
carbamazepine.
Antifungals: increased risk of hypokalaemia with
amphotericin.
Antihypertensives: enhanced hypotensive effect;
increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia
increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk
of ventricular arrhythmias with amisulpride;
enhanced hypotensive effect with phenothiazines;
hypokalaemia increases risk of ventricular
arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of
ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia
occurs.
Ciclosporin: increased risk of nephrotoxicity and
possibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias
due to hypokalaemia with arsenic trioxide; increased
risk of nephrotoxicity and ototoxicity with platinum
compounds.
Lithium: excretion reduced, increased toxicity
Metabolism
Cyclopenthiazide appears to be entirely excreted unchanged in the urine.
Cyclopenthiazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclopenthiazide manufacturers
- Product
- Cyclopenthiazide 742-20-1
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Cyclopenthiazide 742-20-1
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-11
- Product
- Cyclopenthiazide 742-20-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11