ChemicalBook > CAS DataBase List > N-3-thienylacetamide

N-3-thienylacetamide

Product Name
N-3-thienylacetamide
CAS No.
42602-67-5
Chemical Name
N-3-thienylacetamide
Synonyms
N-3-thienylacetamide;3-ACETAMIDOTHIOPHENE;Acetamide, N-3-thienyl-;N-(Thiophen-3-yl)acetamide;N-(Thiophen-3-yl)acetamide - [T43173]
CBNumber
CB2926856
Molecular Formula
C6H7NOS
Formula Weight
141.19
MOL File
42602-67-5.mol
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N-3-thienylacetamide Property

Melting point:
147-148 °C
Boiling point:
325.0±15.0 °C(Predicted)
Density 
1.260±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
Pale yellow flakes
pka
14.96±0.70(Predicted)
Appearance
Light green to green Solid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S943886
Product name
N-(3-THIENYL)ACETAMIDE
Purity
AldrichCPR
Packaging
50MG
Price
$113
Updated
2025/07/31
TRC
Product number
T430048
Product name
N-(3-Thienyl)acetamide
Packaging
500mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
7173AJ
Product name
N-(3-Thienyl)acetamide
Packaging
5g
Price
$259
Updated
2021/12/16
AK Scientific
Product number
7173AJ
Product name
N-(3-Thienyl)acetamide
Packaging
10g
Price
$389
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0293061
Product name
N-(3-THIENYL)ACETAMIDE
Purity
95.00%
Packaging
1G
Price
$750.68
Updated
2021/12/16
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N-3-thienylacetamide Chemical Properties,Usage,Production

Synthesis

17721-06-1

108-24-7

42602-67-5

3-Aminothiophene (1.08 g, 10.9 mmol) was dissolved in ethanoic anhydride (20 mL) and the reaction was stirred for 3 hours at room temperature. After the reaction was completed, water (50 mL) was added and stirring was continued for 30 minutes. Subsequently, the pH was adjusted to >9 by slowly adding 4 M aqueous sodium hydroxide (150 mL). the reaction mixture was extracted with dichloromethane (3 x 100 mL). The organic phases were combined, washed with brine (30 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was crystallized by dichloromethane/petroleum ether mixed solvent to afford N-(3-thienyl)acetamide (994 mg, 65% yield) as a white crystalline solid. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3) and 13C-NMR (125 MHz, CDCl3): 1H-NMR δ 2.17 (s, 3H, CH3), 7.00 (dd, J = 5.0, 1.3 Hz, 1H, Ar-H), 7.23 (dd, J = 5.0, 3.2 Hz, 1H, Ar-H) 7.45 (br, 1H, N-H), 7.55 (dd, J = 3.2, 1.3 Hz, 1H, Ar-H); 13C-NMR δ 18.64 (CH3), 105.03, 115.64, 119.26, 130.27 (Arom-C), 162.11 (C=O).

References

[1] Patent: US2009/247579, 2009, A1. Location in patent: Page/Page column 44
[2] Patent: WO2015/66371, 2015, A1. Location in patent: Paragraph 00478-00479

N-3-thienylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-3-thienylacetamide manufacturers

R&D Scientific Inc.
Product
N-3-Thienylacetamide 42602-67-5
Price
US $2100.00/g
Min. Order
1g
Purity
96
Supply Ability
50 Kg
Release date
2024-02-29