ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
- Product Name
- ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
- CAS No.
- 53786-45-1
- Chemical Name
- ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate
- Synonyms
- Einecs 258-775-8;Domperidone Impurity 8;Domperidone Impurity 2;Domperidone Impurity 28;ethyl 4-((2-amino-4-chlorophenyl);ETHYL 4-(2-AMINO-4-CHLOROANILINO)PIPERIDINE-1-CARBOXYLATE;ETHYL 4-(2-AMINO-4-CHLOROANILINO)-1-PIPERIDINECARBOXYLATE;ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxyl...;ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate;4-[(2-Amino-4-chlorophenyl)amino]-1-piperidinecarboxylic acid ethyl ester
- CBNumber
- CB2930448
- Molecular Formula
- C14H20ClN3O2
- Formula Weight
- 297.78
- MOL File
- 53786-45-1.mol
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Property
- Boiling point:
- 475.6±45.0 °C(Predicted)
- Density
- 1.290±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.70±0.11(Predicted)
- InChI
- InChI=1S/C14H20ClN3O2/c1-2-20-14(19)18-7-5-11(6-8-18)17-13-4-3-10(15)9-12(13)16/h3-4,9,11,17H,2,5-8,16H2,1H3
- InChIKey
- PPCPQDDCMQRJLS-UHFFFAOYSA-N
- SMILES
- N1(C(OCC)=O)CCC(NC2=CC=C(Cl)C=C2N)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Z4845
- Product name
- Ethyl4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate
- Packaging
- 1g
- Price
- $292
- Updated
- 2021/12/16
- Product number
- 126682
- Product name
- Ethyl4-((2-amino-4-chlorophenyl)-amino)piperidine-1-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- HCH0323928
- Product name
- ETHYL 4-[(2-AMINO-4-CHLOROPHENYL)AMINO]PIPERIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.61
- Updated
- 2021/12/16
- Product number
- 126682
- Product name
- Ethyl4-((2-amino-4-chlorophenyl)-amino)piperidine-1-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $1296
- Updated
- 2021/12/16
- Product number
- A303768
- Product name
- Ethyl4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $23
- Updated
- 2021/12/16
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 4-((2-Amino-4-chlorophenyl)amino)piperidine-1-carboxylate is an impurity of Domperidone(D531100); a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
Synthesis
53786-44-0
53786-45-1
2. 1.34 kg of the crude product (domperidone impurity 7) obtained in the first step was dissolved in a solvent mixture of 15 L of methanol and 15 L of tetrahydrofuran with 1.3 L of water. Subsequently, zinc powder and 1.1 kg of ammonium chloride were added and the reaction was carried out at 25 °C for 5 hours. After completion of the reaction, the zinc powder was removed by filtration. Methanol and tetrahydrofuran were recovered by concentration under reduced pressure. The residue was dissolved in 15 L of ethyl acetate and the organic phase was washed with 15 L of water. The organic phase was recrystallized by adding 1 kg of ethyl acetate and 3 kg of petroleum ether to give 1.06 kg of an off-white solid, domperidone intermediate (DP-2), with 99% purity and 88% yield.
References
[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 5, p. 814 - 820
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 19, p. 5052 - 5056
[3] Patent: US4470989, 1984, A
[4] Patent: CN108358832, 2018, A. Location in patent: Paragraph 0007; 0020; 0023; 0029; 0033; 0037
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate Suppliers
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View Lastest Price from ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate manufacturers
- Product
- Ethyl 4-((2-amino-4-chlorophenyl)amino)piperidine-1-carboxylate 53786-45-1
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate 53786-45-1
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12