17-GMP-APA-GA Property

storage temp. 

-20°

solubility 

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).

form 

solid

color 

Purple

Stability:

Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be made fresh and used within 1 working day.

Hazard and Precautionary Statements (GHS)

17-GMP-APA-GA Chemical Properties,Usage,Production

Description

17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.

Uses

17-GMP-APA-GA is an analog of geldanamycin(G304500) with modified linker for coupling proteins/antibodies for the preparation of immunoconjugates.

References

1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460 2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786 3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573