4,4-dimethylpiperidinium chloride
- Product Name
- 4,4-dimethylpiperidinium chloride
- CAS No.
- 38646-68-3
- Chemical Name
- 4,4-dimethylpiperidinium chloride
- Synonyms
- 4,4-Dimethylpiperidine HCl;4,4-dimethylpiperidine hy...;4,4-Dimethyl-piperidine x HCl;4,4-dimethylpiperidinium chloride;4,4-Dimethylpiperidinium hydrochloride;4,4-dimethyl-2,3,5,6-tetrahydropyridin-1-ylium chloride
- CBNumber
- CB2940254
- Molecular Formula
- C7H16ClN
- Formula Weight
- 149.66164
- MOL File
- 38646-68-3.mol
4,4-dimethylpiperidinium chloride Property
- Melting point:
- 227-228℃
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H15N.ClH/c1-7(2)3-5-8-6-4-7;/h8H,3-6H2,1-2H3;1H
- InChIKey
- HQQCRVHZMQHQOA-UHFFFAOYSA-N
- SMILES
- C1(C)(C)CCNCC1.Cl
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H330Fatal if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D480943
- Product name
- 4,4-DimethylpiperidineHydrochloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 027103
- Product name
- 4,4-Dimethylpiperidine hydrochloride
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- FD143986
- Product name
- 4,4-Dimethylpiperidine hydrochloride
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 3H31-5-33
- Product name
- 4,4-Dimethylpiperidine hydrochloride
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- FD143986
- Product name
- 4,4-Dimethylpiperidine hydrochloride
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
4,4-dimethylpiperidinium chloride Chemical Properties,Usage,Production
Synthesis
1123-40-6
38646-68-3
The general procedure for the synthesis of 4,4-dimethylpiperidine hydrochloride from 3,3-dimethylglutamine is as follows: 1. Preparation of 4,4-dimethylpiperidine: Under argon protection, solid lithium aluminum hydride (2.5 g, 64 mmol) was added to a 500 mL round-bottom flask, and 40 mL of anhydrous tetrahydrofuran was added slowly. The suspension was cooled to 0 °C and then a solution of 3,3-dimethylglutarimide (3.0 g, 21 mmol) dissolved in 20 mL of anhydrous tetrahydrofuran was slowly added. Gas was observed to escape during the reaction. After the addition was completed, the ice bath was removed and the reaction mixture was allowed to gradually warm up to room temperature. A condenser was installed and the flask was placed in an oil bath and heated to reflux for 3 hours. 2. Post-treatment: The reaction solution is cooled to room temperature and the flask is subsequently placed in a cold water bath. 2.5mL of water, 2.5mL of 15% aqueous sodium hydroxide solution and 7.5mL of water were added slowly and dropwise to produce a thick suspension. Add 150mL of dry ether, stir and filter to remove solids. Separate the organic layer, dry with anhydrous sodium sulfate and filter. 3. Salt formation: The organic solution was cooled in an ice bath and anhydrous hydrogen chloride gas was passed for 30 seconds to produce a thick white precipitate. The solid was collected by filtration to give 4,4-dimethylpiperidine hydrochloride (2.68 g, 85% yield). Mass spectrometry analysis (APCI+): m/z 114.1.
References
[1] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 11, p. 1971 - 1986
[2] Patent: WO2008/84300, 2008, A1. Location in patent: Page/Page column 57
4,4-dimethylpiperidinium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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