6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide

Application

Product Name: 6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide
CAS No.: 22952-24-5
Chemical Name: 6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide
Synonyms: Nitrosaccharin;6-Nitrosaccharin;6-Nitrobenzo[d]isothiazol-3(2H);6-Nitro-1,1-dioxo-1,2-benzothiazol-3-one;6-Nitro-1,2-benzisothiazol-3-one 1,1-Dioxide;6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide;6-Nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide;6-Nitro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide;1,2-Benzisothiazol-3(2H)-One,6-Nitro,1,1-Dioxide;6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide USP/EP/BP
CBNumber: CB2947460
Molecular Formula: C7H4N2O5S
Formula Weight: 228.18
MOL File: 22952-24-5.mol

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6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide Property

Melting point:: 205-207 °C
Density: 1.762±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 0?+-.0.30(Predicted)
color: Off-white
CAS DataBase Reference: 22952-24-5(CAS DataBase Reference)

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Safety

HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N495025
Product name: 6-Nitrobenzo[d]isothiazol-3(2H)-one1,1-Dioxide
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: N495025
Product name: 6-Nitrobenzo[d]isothiazol-3(2H)-one1,1-Dioxide
Packaging: 500mg
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165592
Product name: 6-NITRO-1,2-BENZISOTHIAZOLIN-3-ONE 1,1-DIOXIDE
Purity: 95.00%
Packaging: 1G
Price: $806.19
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165592
Product name: 6-NITRO-1,2-BENZISOTHIAZOLIN-3-ONE 1,1-DIOXIDE
Purity: 95.00%
Packaging: 5G
Price: $1365.21
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165592
Product name: 6-NITRO-1,2-BENZISOTHIAZOLIN-3-ONE 1,1-DIOXIDE
Purity: 95.00%
Packaging: 10G
Price: $1924.23
Updated: 2021/12/16

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6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide Chemical Properties,Usage,Production

Application

6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide is an organic intermediate that can be prepared from p-nitrotoluene in two steps. It has been reported in the literature as a potential candidate for synthesizing novel probes based on spatially induced electron transfer (SPET).

Synthesis

6269-91-6

22952-24-5

General procedure for the synthesis of 6-nitro-1,2-benzisothiazolin-3-one 1,1-dioxide from 2-methyl-5-nitrobenzenesulfonamide: A solution of chromium trioxide (20.4 g, 0.204 mol) in water (150 mL) was added drop-wise to concentrated sulfuric acid (190 mL) under ice-bath conditions. Subsequently, 2-methyl-5-nitrobenzenesulfonamide (10 g, 46.3 mmol) was added and the reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the mixture was filtered and the residue was washed with water and then dissolved in sodium bicarbonate solution and filtered again under vacuum. The filtrate was acidified with concentrated hydrochloric acid to precipitate. The precipitated product was collected by filtration and washed with plenty of cold water. Finally, the product was dried in a vacuum oven at 40°C to give a white powder in 72% yield. The melting point of the product was 205.6-205.8 °C (literature value: 205-207 °C); IR spectra showed characteristic absorption peaks located at 3103, 1720, 1608, 1541, 1354, 1340, 1184, 1128 cm-1 ; 1H NMR (DMSO-d6, 300 MHz) δ/ ppm: 8.02 (1H, d, J = 8.5 Hz), 8.56 (1H, d, J = 8.2 Hz), 8.71 (1H, s), 10.2 (1H, br, NH); 13C NMR (DMSO-d6, 75 MHz) δ/ ppm: 117.2, 126.4, 129.8, 135.2, 143.0, 151.7, 162.2.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 9, p. 2811 - 2821
[2] Asian Journal of Chemistry, 2017, vol. 29, # 7, p. 1622 - 1624
[3] Patent: WO2012/48222, 2012, A1. Location in patent: Page/Page column 98
[4] Tetrahedron, 2006, vol. 62, # 33, p. 7902 - 7910
[5] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 12, p. 3824 - 3827

6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide Preparation Products And Raw materials

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6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide Suppliers

China 68 India 1 United Kingdom 2 United States 5 Global 76

Beijing Ouhe Technology Co., Ltd

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View Lastest Price from 6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide 22952-24-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 95.0%
Supply Ability: 10000KGS
Release date: 2025-02-28

Career Henan Chemical Co

Product: 6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide 22952-24-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-02-04

22952-24-5, 6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxideRelated Search:

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6-Nitro-1,1-dioxo-1,2-benzothiazol-3-one

6-Nitro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide

6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide

Nitrosaccharin

6-nitro-2,3-dihydro-1$l^{6},2-benzothiazole-1,1,3-trione

1,2-Benzisothiazol-3(2H)-One,6-Nitro,1,1-Dioxide

6-Nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

6-Nitrosaccharin

6-Nitrobenzo[d]isothiazol-3(2H)

6-Nitro-1,2-benzisothiazol-3-one 1,1-Dioxide

6-Nitro-1,2-benzisothiazolin-3-one 1,1-dioxide USP/EP/BP

1,2-Benzisothiazol-3(2H)-one, 6-nitro-, 1,1-dioxide (9CI, ACI)

6-nitro-1,2-Benzisothiazol-3(2H)-one 1,1-dioxide (9CI ACI)

22952-24-5

C7H4N2O5S