ChemicalBook > CAS DataBase List > Davercin

Davercin

Product Name
Davercin
CAS No.
55224-05-0
Chemical Name
Davercin
Synonyms
erythromycin A cyclic 11,12-carbonate;CWE;DAVERCIN;Dravercin;Davercin USP/EP/BP;Erythromycin cycloester;Eritromicina A carbonato;Erythromycin Impurity 10;Erythromycin Impurity 50;Erythromycin Cyclocarbonate
CBNumber
CB2966540
Molecular Formula
C38H65NO14
Formula Weight
759.93
MOL File
55224-05-0.mol
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Davercin Property

Melting point:
>135°C (dec.)
Boiling point:
859.8±65.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
13.49±0.70(Predicted)
form 
Solid
color 
White
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Safety

Toxicity
LD50 oral in rat: 5800mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
1mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
5mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
10mg
Price
$332
Updated
2024/03/01
Cayman Chemical
Product number
21348
Product name
Davercin
Purity
≥98%
Packaging
25mg
Price
$746
Updated
2024/03/01
TRC
Product number
E650045
Product name
ErythromycinCyclocarbonate
Packaging
2.5mg
Price
$110
Updated
2021/12/16
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Davercin Chemical Properties,Usage,Production

Description

Davercin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It has broad-spectrum activity against various Gram-positive and Gram-negative bacteria (MICs = 0.02-50 μg/ml). Davercin is non-toxic to mice and rats (LD50s = 4.05 and 5.9 g/kg, respectively). Formulations containing davercin have been used to treat a variety of urogenital bacterial infections.

Uses

Davercin (erythromycin A cyclic 11,12-carbonate) is a first generation semi-synthetic erythromycin. Davercin is prepared by coupling the 11- and 12-OH groups to form a cyclic carbonate. This simple modification improves the stability and hydrophobicity of the macrocyclic structure. Davercin shows comparable or better in vitro potency, low host toxicity and improved pharmacokinetics compared with erythromycin.

Uses

Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.

Definition

ChEBI: Davercin is an aminoglycoside.

Davercin Preparation Products And Raw materials

Raw materials

Preparation Products

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Davercin Suppliers

China 99 China Hong Kong 1 India 4 United Kingdom 1 United States 16 Global 121
Adamas Reagent, Ltd.
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View Lastest Price from Davercin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Davercin 55224-05-0
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07
Career Henan Chemical Co
Product
Davercin 55224-05-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 784
Release date
2019-09-02

55224-05-0, DavercinRelated Search:

Erythromycin 3-Dimethylaminopropylamine CYCLANDELATE CHLOROPHOSPHONAZO III Dimethyl carbonate Ethylene carbonate Lithium carbonate Calcium carbonate Sodium carbonate Roxithromycin CYCLOPENTOLATE Erythromycin Impurity 9 DIBUTYL CARBONATE 4-ETHYL-1,3-DIOXOLAN-2-ONE (S)-(-)-Propylene Carbonate (R)-(+)-Propylene carbonate 4-HYDROXYMETHYL-1,3-DIOXOLAN-2-ONE (R)-(+)-4-(METHOXYMETHYL)-1,3-DIOXOLAN-2-ONE

  • Erythromycin Cyclocarbonate
  • DAVERCIN
  • CWE
  • erythromycin A cyclic 11,12-carbonate
  • (1R,2R,5R,6S,7S,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione
  • Carbonato ciclico de eritromicina a
  • Carbonato ciclico de eritromicina A [spanish]
  • Cykliczny weglan erytromycyny a
  • Cykliczny weglan erytromycyny A [polish]
  • Dravercin
  • Eritromicina A carbonato
  • Eritromicina A carbonato [spanish]
  • ErythroMycin A 11,12-carbonate, ErythroMycin A cyclic 11,12-carbonate, ErythroMycin cyclic carbonate
  • Cyclic ester of erythroMycin
  • cyclic 11,12-carbonate erythromycin
  • Erythromycin Impurity 10
  • Erythromycin Cyclocarbonate, >98%
  • Erythromycin, cyclic 11,12-carbonate
  • Erythromycin Impurity 20（Erythromycin Cyclocarbonate）
  • Davercin USP/EP/BP
  • Erythromycin Cyclic11,12-Carbonate(Davercin)
  • Erythromycin Impurity 50
  • (3aR,4R,7R,8S,9S,10R,11R,13R,15R,15aR)-10-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-hydroxy-8-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3a,7,9,11,13,15-hexamethyloctahy
  • Davercin (Erythromycin cyclocarbonate)
  • Erythromycin cycloester
  • Erythromycin cyclic carbonate
  • Erythromycin Impurity 10(Davercin)
  • 55224-05-0
  • C38H65NO14
  • Inhibitors
  • 55224-05-0