ChemicalBook > CAS DataBase List > 5-Hydroxy-1-methylpyrazole

5-Hydroxy-1-methylpyrazole

Product Name
5-Hydroxy-1-methylpyrazole
CAS No.
33641-15-5
Chemical Name
5-Hydroxy-1-methylpyrazole
Synonyms
1-methyl-1H-pyrazol-5-ol;1-Methyl-1H-pyrazol-3(2H)-one;33641-15-5;Topramezon-001;1-Methylpyrazol-5-ol;2-methylpyrazol-3-ol;-Methyl-1H-pyrazol-5-ol;2-Methyl-2H-pyrazol-3-ol;1-methyl-5-hydroxypyrazol;1-Methyl-5-hydroxypyrazole
CBNumber
CB2971487
Molecular Formula
C4H6N2O
Formula Weight
98.1
MOL File
33641-15-5.mol
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5-Hydroxy-1-methylpyrazole Property

Melting point:
110-114 °C
Boiling point:
217.7±13.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in DMSO, Methanol
form 
powder to crystal
pka
9.07±0.23(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C4H6N2O/c1-6-4(7)2-3-5-6/h2-3,7H,1H3
InChIKey
CMXOTACIOGGSNH-UHFFFAOYSA-N
SMILES
N1(C)C(O)=CC=N1
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
747831
Product name
5-Hydroxy-1-methyl-1H-pyrazole
Purity
97%
Packaging
1g
Price
$104
Updated
2023/06/20
TCI Chemical
Product number
H1695
Product name
5-Hydroxy-1-methyl-1H-pyrazole
Packaging
1G
Price
$65
Updated
2025/07/31
TCI Chemical
Product number
H1695
Product name
5-Hydroxy-1-methyl-1H-pyrazole
Packaging
5G
Price
$217
Updated
2025/07/31
TRC
Product number
H948380
Product name
5-Hydroxy-1-methylpyrazole
Packaging
5g
Price
$300
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-1R
Product name
1-Methyl-1H-pyrazol-5-ol
Purity
97%
Packaging
10g
Price
$184
Updated
2021/12/16
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5-Hydroxy-1-methylpyrazole Chemical Properties,Usage,Production

Uses

5-Hydroxy-1-methylpyrazole is a pyrazole derivative used as an intermediate in the preparation of herbicides.

Synthesis

88398-78-1

33641-15-5

The general procedure for the synthesis of 1-methyl-5-hydroxypyrazole-4-carboxylic acid from ethyl 1-methyl-5-hydroxypyrazole-4-carboxylate is as follows: 22 g of sodium hydroxide was dissolved in 300 mL of water, 42.5 g of intermediate (ethyl 1-methyl-5-hydroxypyrazole-4-carboxylate) was added, and the reaction was stirred for 3 hr at 40 °C, then cooled to room temperature. 55 mL of concentrated hydrochloric acid was added dropwise, followed by heating and refluxing for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, 200 mL of anhydrous ethanol was added to the residue, and the precipitate was collected by filtration after thorough stirring. The filtrate was concentrated under reduced pressure to give 24 g of white solid product (1-methyl-5-hydroxypyrazole) in 98.0% yield and 96.50% HPLC purity.

References

[1] Patent: CN105218449, 2016, A. Location in patent: Paragraph 0063; 006=5

5-Hydroxy-1-methylpyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Hydroxy-1-methylpyrazole manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
5-Hydroxy-1-methylpyrazole 33641-15-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20TON
Release date
2024-12-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
5-Hydroxy-1-Methylpyrazole 33641-15-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-14
Shaanxi Dideu Medichem Co. Ltd
Product
5-Hydroxy-1-methylpyrazole 33641-15-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-15

33641-15-5, 5-Hydroxy-1-methylpyrazoleRelated Search:

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  • 5-HYDROXY-1-METHYL-1H-PYRAZOLE, 95%
  • 1-methyl-5-hydroxypyrazol
  • 1-methyl-1H-pyrazol-5-ol
  • REF DUPL: 5-Hydroxy-1-methyl-1H-pyrazole
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  • 1-Methyl-5-hydroxypyrazole
  • 1-Methylpyrazol-5-ol
  • 5-Hydroxy-1-Methyl-5-pyrazole
  • 1-Methyl-1H-pyrazol-3(2H)-one
  • 2-Methyl-2H-pyrazol-3-ol
  • 2-methylpyrazol-3-ol
  • -Methyl-1H-pyrazol-5-ol
  • Topramezon-001
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  • 5-Hydroxy-1-methylpyrazole，97%
  • 5-HYDROXY-1-METHYLPYRAZOLE
  • 5-Hydroxy-1-methyl-1<i>H</i>-pyrazole
  • 33641-15-5
  • 5-Hydroxy-1-methylpyrazole 98%
  • 33641-15-5
  • Heterocyclic Compounds
  • Aromatics
  • Heterocycles
  • Intermediates