ChemicalBook > CAS DataBase List > N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate

N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate

Product Name
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate
CAS No.
212333-72-7
Chemical Name
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate
Synonyms
HOTT;HOTTU;N,N,N',N'-Tetramethy;HOTT N,N,N'',N''-TETR;S-(1-Oxido-2-pyridyl)-N,N,N',N'-tetramethylthiuron;N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuron;S-(1-OXIDO-2-PYRIDYL)-N,N,N',N'-TETRAMETHYLTHIURONIUM-PF6;N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafl...;-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate;N,N,N',N'-TetraMethyl-S-(1-oxido-2-pyridyl)thiuronhexafluorophosphate
CBNumber
CB2972338
Molecular Formula
C10H16N3OS.F6P
Formula Weight
371.28
MOL File
212333-72-7.mol
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N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate Property

Melting point:
120-125 °C
storage temp. 
-20°C
solubility 
acetonitrile, CH2Cl2, THF (moderate solubility)
form 
Powder
color 
White to yellow
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C10H16N3OS.F6P/c1-11(2)10(12(3)4)15-9-7-5-6-8-13(9)14;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
InChIKey
UCOGEMMJHLHOAW-UHFFFAOYSA-N
SMILES
[S+](C1=CC=CC=[N+]1[O-])=C(N(C)C)N(C)C.[P-](F)(F)(F)(F)(F)F
CAS DataBase Reference
212333-72-7(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
94624
Product name
S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate
Purity
≥95.0%(NMR)
Packaging
5G
Price
$144
Updated
2023/01/07
Sigma-Aldrich
Product number
94624
Product name
S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate
Purity
≥95.0%(NMR)
Packaging
25g
Price
$682
Updated
2023/01/07
TCI Chemical
Product number
T2821
Product name
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$58
Updated
2025/07/31
TRC
Product number
T303730
Product name
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate
Packaging
5g
Price
$140
Updated
2021/12/16
Chem-Impex
Product number
31213
Product name
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouroniumhexafluorophosphate,99%(HPLC)
Purity
99%(HPLC)
Packaging
1G
Price
$11.2
Updated
2021/12/16
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N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate Chemical Properties,Usage,Production

Chemical Properties

N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate is white to pale brown crystalline powder

Uses

N,N,N’N’Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate is a reagent used in the preparation of hindered Barton esters from hindered carboxylic acid precursors. N,N,N’N’Tetramethy l-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate is also used as a coupling reagents for peptide bond formations and amidation reactions.

Uses

N,N,N’,N’-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate is a reagent used in the preparation of hindered Barton esters from hindered carboxylic acid precursors. N,N,N’,N’-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate is also used as a coupling reagents for peptide bond formations and amidation reactions.

reaction suitability

reaction type: Coupling Reactions

Synthesis

S-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium Hexafluorophosphate (HOTT) can be prepared by slowly adding Et3N to a dry CH2Cl2 solution of 2-mercaptopyridine-N-oxide and tetramethylchloroformamidinium hexafluorophosphate. After the removal of CH2Cl2 from the reaction mixture, the resulting solid mass is pulverized, washed with CHCl3, and then filtered to give a white solid of sufficient purity to be used in subsequent reactions.

Precautions

It is advised to protect the solid from prolonged exposure to light since 2- mercaptopyridine N-oxide and related compounds can be light-sensitive.

N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate Suppliers

Canada 1 China 111 Germany 1 India 3 Japan 1 Switzerland 1 United Kingdom 1 United States 10 Global 129
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate 212333-72-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
N,N,N",N"-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate 212333-72-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N,N,N",N"-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate 212333-72-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

212333-72-7, N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphateRelated Search:

Potassium hexafluorophosphate 2,4,6-Collidine 4-Methylpyridine Lithium hexafluorophosphate Hexafluorophosphoric acid 2,6-Lutidine Azamethiphos Tetramethylthiourea HPTDP 2-PYRIDYLTHIOUREA Hott(S-(1-Oxo-2-Pyridyl)-Thio-N,N,N'N'-TetramethyluroniumHexafluorophosphate) N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate

  • S-(1-OXIDO-2-PYRIDYL)-N,N,N',N'-TETRAMETHYLTHIURONIUM-PF6
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuron
  • S-(1-Oxido-2-pyridyl)-N,N,N',N'-tetramethylthiuron
  • HOTT N,N,N'',N''-TETRAMETHYL-S-(1-OXIDO-2-PYRIDYL)THIURONIUM HEXAFLUOROPHOSPHATE
  • HOTT
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate
  • S-(1-Oxido-2-pyridyl)-thio-N,N,N,N-tetramethyluronium hexafluorophosphate
  • S-(2-Pyridyl)-N,N,Nμ,Nμ-tetramethylthiuronium N-oxide hexafluorophosphate, N,N,Nμ,Nμ-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate
  • 2-((dimethylamino)(dimethyliminio)methylthio)pyridine 1-oxide hexafluorophosphate(V)
  • S-(1-Oxido-2-pyridinyl) 1,1,3,3-tetramethylthiouronium hexafluorophosphate
  • HOTTU
  • N,N,N',N'-Tetramethy
  • S-(1-Oxido-2-pyridyl)-N,N,N,N-tetramethylthiuronium hexafluorophosphate R)
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronhexafluorophosphate (HOTT)
  • <i>N</i>,<i>N</i>,<i>N</i>',<i>N</i>'-Tetramethyl-<i>S</i>-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate
  • HOTT N,N,N'',N''-TETR
  • N,N,N',N'-TetraMethyl-S-(1-oxido-2-pyridyl)thiuronhexafluorophosphate
  • S-(1-Oxido-2-pyridyl)-N,N,N',N'-tetraMethylthiuroniuM hexafluorophosphate, 98+%
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium hexafluorophosphate≥ 98%(HPLC)
  • -Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate
  • [dimethylamino-[(1-oxido-2H-pyridin-6-yl)thio]methylidene]-dimethylammonium hexafluorophosphate
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate USP/EP/BP
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafl...
  • Methanaminium, (dimethylamino)dimethyl[(1-oxido-2-pyridinyl)thio]-, hexafluorophosphate(1-) (1:1)
  • (dimethylamino)dimethyl[(1-oxido-2-pyridinyl)thio]-Methanaminium hexafluorophosphate(1-) (1:1)
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Hexafluorophosphate
  • HOTTN,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate
  • <i>S</i>-(1-Oxido-2-pyridyl)-<i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetramethylthiuronium hexafluorophosphate
  • S-(1-Oxido-2-pyridyl)-N,N,N′,N′-tetramethylthiuronium hexafluorophosphate, CAS 212333-72-7
  • N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium hexafluorophosphate
  • 2-((bis(dimethylamino)methylene)sulfonio)pyridine 1-oxide hexafluorophosphate(v)
  • 212333-72-7
  • 12333-72-7
  • C10H17F6N3OPS
  • C10H16F6N3O3PS
  • C10H16F6N3OPS
  • C10H16F6N3POS
  • C10H16N3OSF6P
  • Coupling Reagent