Fmoc-N-amido-PEG24-acid Property

storage temp. 

2-8°C

InChIKey

YYQNCNHFUALMKW-UHFFFAOYSA-N

SMILES

C(O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(C1C2=C(C=CC=C2)C2=C1C=CC=C2)C(OC)=O

Safety

WGK Germany 

3

HS Code 

3822000000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Fmoc-N-amido-PEG24-acid Chemical Properties,Usage,Production

Description

Fmoc-N-amido-PEG24-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

O-(N-Fmoc-2-aminoethyl)-O''-(2-carboxyethyl)undecaethyleneglycol is used as a linker in the preparation of PEG-peptide surfaces as attractive platforms for the development of peptide microarrays.

Application

Some applications of O-[2-(Fmoc-amino)-ethyl]-O'-(2-carboxyethyl)polyethylene glycol 3000 (Fmoc-N-amido-PEG36-acid) include the development of flexible antibodies with non-protein hinges, the development of optimized liposomes for intracellular protein delivery, and the development of conjugates for SPECT imaging of cancer in vivo.