4-NITROSODIPHENYLAMINE Property

Melting point:

144 °C (dec.)(lit.)

Boiling point:

335.53°C (rough estimate)

Density 

1.1447 (rough estimate)

refractive index 

1.6330 (estimate)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated)

form 

Solid

pka

-3.56±0.20(Predicted)

color 

Green plates with bluish luster (from benzene) orsteel-blue prisms or plates (from ether + H2O)

Merck 

14,6639

CAS DataBase Reference

156-10-5(CAS DataBase Reference)

IARC

3 (Vol. 27, Sup 7) 1987

EPA Substance Registry System

p-Nitrosodiphenylamine (156-10-5)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/38

Safety Statements 

26-36/37

RIDADR 

2811

WGK Germany 

3

RTECS 

JK0175000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29214200

Hazardous Substances Data

156-10-5(Hazardous Substances Data)

Toxicity

LD50 intravenous in mouse: 178mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

4-NITROSODIPHENYLAMINE Chemical Properties,Usage,Production

Chemical Properties

dark blue to black powder

Chemical Properties

TKB is a black powder or a green plate-like material with a bluish luster.

Uses

4-?Nitrosodiphenylamine is used in organic synthesis such as in the preparation of 1-(Phenylamino)pseudo-mauveine water soluble dye. Potential mutagenic compound.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.

Uses

Has been used as retardant in vulcanizing rubber.

Definition

ChEBI: Para-Nitrosodiphenylamine is a member of benzenes.

Synthesis Reference(s)

The Journal of Organic Chemistry, 32, p. 153, 1967 DOI: 10.1021/jo01277a038

General Description

Green plates with bluish luster or a black powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-NITROSODIPHENYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. May react with strong oxidizing agents .

Hazard

Questionable carcinogen.

Fire Hazard

Flash point data for 4-NITROSODIPHENYLAMINE are not available; however, 4-NITROSODIPHENYLAMINE is probably combustible.

Safety Profile

Poison by intravenous route. Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by ingestion. Mutation data reported. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS and AMINES.

Potential Exposure

Used as a chemical intermediate for dyes and pharmaceuticals; in making monomers; and vulcanizing rubber.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

The amine forms dark green crystals from EtOH or *C6H6 (m 143o). It has UV at max 421nm (EtOH) and is used for detecting Pd and Rh. It is highly toxic and a possible carcinogen.[Beilstein 12 H 207, 12 II 122, 12 III 347, 12 IV 1860..]

Incompatibilities

Nitrated organics range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction. Reaction with aliphatic amines can release carcinogenic nitrosamines. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. 4-nitrosodiphenylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrideds and active metals. May react with strong oxidizing agents.