Nipocalimab

Product Name: Nipocalimab
CAS No.: 2211985-36-1
Chemical Name: Nipocalimab
Synonyms: Nipocalimab;Nipocalimab (anti-FcRn);Research Grade Nipocalimab;Research Grade Nipocalimab(DHF14604)
CBNumber: CB310616960
Formula Weight: 0
MOL File: Mol file

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Nipocalimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Nipocalimab Chemical Properties,Usage,Production

Uses

Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases[1][2][3].

in vivo

Nipocalimab (300 mg/kg; once a week; 6 months) can cause a sustained decrease in IgG without adverse effects in non-human primates^[2].

References

[1] James S Castleman, et al. Medical therapy to attenuate fetal anaemia in severe maternal red cell alloimmunisation. Br J Haematol. 2021 Feb;192(3):425-432. DOI:10.1111/bjh.17041
[2] Ling L E, et al. Selective targeting of FcRn and IgG clearance by nipocalimab preserves key immune functions. Hematology, Transfusion and Cell Therapy, 2022, 44: S13.
[3] Marinos C Dalakas, et al. The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors. Ther Adv Neurol Disord. 2021 Feb 26;14:1756286421997381. DOI:10.1177/1756286421997381

Nipocalimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Nipocalimab Suppliers

China 14 Global 14

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2211985-36-1, NipocalimabRelated Search:

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Nipocalimab

Research Grade Nipocalimab(DHF14604)

Research Grade Nipocalimab

Nipocalimab (anti-FcRn)

2211985-36-1