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Alosetron hydrochloride

Product Name
Alosetron hydrochloride
CAS No.
122852-69-1
Chemical Name
Alosetron hydrochloride
Synonyms
Lotronex;ALOSETRON HCL;GR 68755;GR 68755X;GR 68755C;Alosetron hydrocloride;ALOSETRON HYDROCHLORIDE;Alosetron hydrochloride salt;Alosetron hydrochloride USP/EP/BP;Cc1[nH]cnc1CN2CCc4c(C2=O)c3ccccc3n4C.Cl
CBNumber
CB3107074
Molecular Formula
C17H19ClN4O
Formula Weight
330.81
MOL File
122852-69-1.mol
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Alosetron hydrochloride Property

Melting point:
288-291°C
storage temp. 
2-8°C
solubility 
H2O: ≥5mg/mL at warmed
form 
powder
color 
white to beige
CAS DataBase Reference
122852-69-1(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36-52/53
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933790002
Hazardous Substances Data
122852-69-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0346
Product name
Alosetron hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$79.5
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0346
Product name
Alosetron hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$308
Updated
2024/03/01
TCI Chemical
Product number
A3197
Product name
Alosetron Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
22434
Product name
Alosetron (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
22434
Product name
Alosetron (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$40
Updated
2024/03/01
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Alosetron hydrochloride Chemical Properties,Usage,Production

Description

Lotronex (alosetron) was developed for the treatment of severe irritable bowel syndrome (IBS), and was approved for use by the US Food and Drug Administration (FDA) in 2000. Although Lotronex had a relatively high improvement rate in patients taking the drug for IBS, it was voluntarily pulled from the market by GlaxoWellcome that same year due to reports of severe adverse side effects, some resulting in death.
In 2002, Lotronex was reapproved in a supplemental New Drug Application for use under more restrictive conditions. Now with a risk management program to be consulted prior to administration of the drug, Lotronex is designated to be prescribed only when its medical benefits outweigh the risks of toxic effects; women with severe diarrhea-predominant IBS are now the focal point of prescriptions for Lotronex.

Chemical Properties

Alosetron hydrochloride is Crystalline Solid

Originator

Alosetron hydrochloride,GlaxoSmithKline

Uses

Lotronex is used for severe diarrhea-predominant IBS in women. There are other potential uses, as animal models have shown at least some evidence for the ability of Lotronex to mitigate the effects of psychosis, anxiety, cognitive impairment, emesis, and drug withdrawal. These possibilities have not been verified in humans, however.

Uses

Alosetron hydrochloride is used in treatment of irritable bowel syndrome

Definition

ChEBI: The hydrochloride salt of alosetron.

Manufacturing Process

4-(Chloromethyl)-1-(triphenylmethyl)-1H-imidazole.
Thionyl chloride (0.829 g) was added over 1 min to a stirred suspension of 1- (triphenylmethyl)-1H-imidazole-4-methanol (1.3 g) in a mixture of dichloromethane (50 ml) and DMF (1.0 ml) at 23°C. The solution so obtained was stirred for 15 min. and extracted with 8% sodium bicarbonate solution (80 ml). The organic phase was washed with water (50 ml), dried and evaporated to give an oil which solidified. The solid was slurried in hexane and filtered to give the title compound (1.28 g), m.p. 139-141°C.
3,4-Dihydro-4-methylcyclopent[b]indol-1(2H)-one oxime.
3,4-Dihydro-4-methylcyclopent[b]indol-1(2H)-one (1.7 g) and hydroxylamine hydrochloride (1.925 g) in pyridine were heated at 60°C for 18 h and cooled. The reaction mixture was evaporated in vacuo to a residue to which was added 8% sodium bicarbonate (150 ml). Extraction with ethyl acetate (300 ml) produced a suspension in the organic layer; this layer and associated solid was separated from the aqueous layer. The aqueous layer was re-extracted with ethyl acetate (250 ml). The combined organic extracts (and suspended solid) were evaporated to a residue, boiled with a mixture of ethanol (150 ml) and methanol (150 ml) and cooled to 50°C. The residue was adsorbed from this solution on to FCC silica and applied to an FCC column. Elution with ethyl acetate/3-10% methanol provided the title compound (1.69 g), m.p. 219- 224°C (decomp.).
2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one.
3,4-Dihydro-4-methylcyclopent[b]indol-1(2H)-one oxime (1.53 g), polyphosphoric acid (409 g) and dioxan (15 ml) were heated at 110-120°C for 2.2 h under nitrogen. The reaction mixture was cooled, and treated with 2 N sodium carbonate solution (1 L). The suspension was extracted with ethyl acetate (4x400 ml) and the combined extracts were dried. Evaporation gave a solid (1.43 g) which was recrystallised from ethyl acetate/cyclohexane. This solid was purified by FCC, eluting with dichloromethane:ethanol:ammonia solution (200:10:1) to give a solid (1.26 g) which was recrystallised from ethanol to provide the title compound (960 mg), m.p. 234-238°C.
2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1Hpyrido[ 4,3-b]indol-1-one maleate.
A mixture of 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (0.6 g) and 78% sodium hydride dispersion in mineral oil (0.109 g) in dry DMF (15 ml) was stirred under nitrogen at 50°C until hydrogen evolution ceased (ca. 1.5 h). The mixture was cooled to 40°C and a solution of 4-(chloromethyl)-5- methyl-1-(triphenylmethyl)-1H-imidazole (1.12 g) in dry THF (15 ml) was added. The reaction was then stirred at 40°C for 3 h, at 20°C for 16 h and a further portion of 4-(chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole (1.12 g) in dry THF (15 ml) was added. The resulting mixture was heated at 40°C for 3 h, quenched with water (20 ml) and acetic acid (20 ml), and heated at 100°C for 2 h. The mixture was then concentrated in vacuo to ca. 60 ml, diluted with 1 M hydrochloric acid (40 ml) and washed with ethyl acetate (3x50 ml). The organic phase was discarded and the acidic aqueous phase was basified (pH=9) with potassium carbonate and extracted with ethyl acetate:ethanol (20:1; 3x100 ml). The extracts were combined, dried and evaporated to give a brown gum (ca. 1 g). This gum was adsorbed onto silica and purified by FCC eluting with dichloromethane:ethanol:ammonia solition (100:8:1) to give a pale brown solid (0.8 g); m.p. 238-240°C (decomp.). This solid was dissolved in a mixture of (hot ethanol and methanol (1:1; 100 ml) and treated with an ethanolic solution of maleic acid (3.18 g). The resulting solution was concentrated to ca. 20 ml and diluted with dry diethyl ether (ca. 8 ml) to precipitate the title compound (0.75 g) as an off-white solid melting point 160-162°C. Hydrochloride may be prepared by treating the above solid with an equivalent of an ethanolic solution of HCl.

brand name

Lotronex (GlaxoSmithKline).

Therapeutic Function

Antidiarrheal

Biochem/physiol Actions

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.

Environmental Fate

The environmental fate and behavior of Lotronex is uncertain, as formal studies regarding its release into the environment are virtually nonexistent in the literature. Limited water solubility (61 mg ml-1) may lead to persistence in soils, and in sediment following aquatic release, although specific fates with regard to degradation, bioaccumulation, and transport are unknown.

Toxicity evaluation

A highly potent and selective 5-HT3 receptor agonist, Lotronex rapidly binds to cation channels that exist on enteric neurons in the human gastrointestinal tract in addition to other central and peripheral locations. Lotronex inhibits the activation of these channels, resulting in effects to the enteric nervous system whereas the activation of these channels regulates (promotes) colonic transit, visceral pain pathways, and gastrointestinal secretions – all of which are processes related to the pathophysiology of IBS. The binding of Lotronex to 5-HT3 receptors reduces the rate at which fecal matter moves through the large intestine and increases water absorption. The toxic effects of Lotronex are related to the relative activation/inactivation of the cation channels responsible for mediating these processes.

Alosetron hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Alosetron hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Alosetron hydrochloride 122852-69-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Alosetron hydrochloride 122852-69-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
alosetron hydrochloride 122852-69-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

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