Marimastat

Product Name: Marimastat
CAS No.: 154039-60-8
Chemical Name: Marimastat
Synonyms: TMH;GI 5712;BB 2516;TA 2516;CS-1627;KB-R 8898;Marimastat;Marimistat;Marimastat(BB-2516);BB 2516; MARIMISTAT
CBNumber: CB31073538
Molecular Formula: C15H29N3O5
Formula Weight: 331.41
MOL File: 154039-60-8.mol

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Marimastat Property

Melting point:: 148℃
Density: 1.140±0.06 g/cm3(Predicted)
RTECS: EJ6665000
storage temp.: -20°C
solubility: DMSO: ≥20mg/mL
form: White solid
pka: 9.44±0.40(Predicted)
color: White to gray

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Safety

WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M2699
Product name: Marimastat
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $221
Updated: 2024/03/01

Sigma-Aldrich

Product number: 444289
Product name: Marimastat
Packaging: 5mg
Price: $289
Updated: 2024/03/01

Alfa Aesar

Product number: J67288
Product name: Marimastat, 98%
Packaging: 1mg
Price: $126
Updated: 2023/06/20

Alfa Aesar

Product number: J67288
Product name: Marimastat, 98%
Packaging: 10mg
Price: $286
Updated: 2023/06/20

Cayman Chemical

Product number: 14869
Product name: Marimastat
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

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Marimastat Chemical Properties,Usage,Production

Uses

Antineoplastic (matrix metalloproteinase inhibitor).

Uses

Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.

Uses

Marimastat has been used as an inhibitor of:

metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in mice
metalloproteinase, to determine protease activity in Pseudomonas aeruginosa cultures
metalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10

Definition

ChEBI: Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid.

General Description

An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC₅₀ in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn²⁺. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.

Biological Activity

Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis.

Biochem/physiol Actions

Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor

storage

Store at -20°C

Marimastat Preparation Products And Raw materials

Raw materials

Preparation Products

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Marimastat Suppliers

China 94 Germany 1 India 1 United Kingdom 2 United States 18 Global 116

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Abcam

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Email: us.orders@abcam.com
Country: United States
ProdList: 6001
Advantage: 50

Cayman Chemical Company

Tel: --
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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

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Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

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Country: United States
ProdList: 6773
Advantage: 87

Selleck Chemicals LLC

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Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

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View Lastest Price from Marimastat manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Marimastat 154039-60-8
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: Marimastat 154039-60-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Marimastat 154039-60-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

154039-60-8, MarimastatRelated Search:

Cilastatin Marimastat HEXANOHYDROXAMIC ACID L-TERT-LEUCINE METHYLAMIDE

Marimastat

(2R,3S)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4,3-dihydroxy-2-isobutylsuccinamide

(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

(2R,3S)-N1-((S)-3,3-diMethyl-1-(MethylaMino)-1-oxobutan-2-yl)-N4

BB 2516

GI 5712

KB-R 8898

TA 2516

Marimastat(BB-2516)

BB2516, (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl] propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

(2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N\',3-dihydroxy-2-(2-methylpropyl)butanediamide

BB 2516; MARIMISTAT

Marimistat

CS-1627

Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-

TMH

BB2516|||KB-R8898|||TA2516

Marimastat, Matrix metalloprotease (MMP) inhibitor

Marimastat, 10 mM in DMSO

154039-60-8

C15H29N3O5

API