2-chloro-5-(trifluoromethyl)-4-iodopyridine

Product Name: 2-chloro-5-(trifluoromethyl)-4-iodopyridine
CAS No.: 505084-55-9
Chemical Name: 2-chloro-5-(trifluoromethyl)-4-iodopyridine
Synonyms: CAS:505084-55-9;505084-55-9;chloro-5-(trifluoromethyl)-4-iodopyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine;2-CHLORO-5-(TRIFLUOROMETHYL)-4-IODOPHRIDINE;2-chloro-5-(trifluoromethyl)-4-iodopyridine;Pyridine, 2-chloro-4-iodo-5-(trifluoromethyl)-;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine >2-chloro -4-iodine -5- threefluorineMethyl pyridine;2-Chloro-4-iodo-5-(trifluoromethyl)pyridine,tech.90%
CBNumber: CB31094122
Molecular Formula: C6H2ClF3IN
Formula Weight: 307.44
MOL File: 505084-55-9.mol

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2-chloro-5-(trifluoromethyl)-4-iodopyridine Property

Melting point:: 126.0 to 130.0 °C
Boiling point:: 257.6±40.0 °C(Predicted)
Density: 2.046±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Solid
pka: -2.74±0.10(Predicted)
color: Light Tan
Sensitive: Light Sensitive
InChI: InChI=1S/C6H2ClF3IN/c7-5-1-4(11)3(2-12-5)6(8,9)10/h1-2H
InChIKey: XEEQBBXEZSNIQV-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(C(F)(F)F)C(I)=C1
CAS DataBase Reference: 505084-55-9

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2999
Product name: 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: C2999
Product name: 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $180
Updated: 2025/07/31

TRC

Product number: C367325
Product name: 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
Packaging: 5G
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC30782
Product name: 2-Chloro-4-iodo-5-(trifluoromethyl)-pyridine
Packaging: 25g
Price: $400
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 50285
Product name: 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine
Packaging: 1g
Price: $620
Updated: 2021/12/16

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2-chloro-5-(trifluoromethyl)-4-iodopyridine Chemical Properties,Usage,Production

Uses

2-Chloro-4-iodo-5-(trifluoromethyl)pyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.

Uses

2-chloro-5-(trifluoromethyl)-4-iodopyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.

Synthesis

52334-81-3

505084-55-9

The general procedure for the synthesis of 2-chloro-5-trifluoromethyl-4-iodopyridine from 2-chloro-5-trifluoromethylpyridine was as follows: diisopropylamine (3.3330 g, 32.94 mmol) and anhydrous THF (33 mL) were added to 100 mL of a cigar shaped flask and protected under Ar atmosphere. The reaction system was cooled to -78 °C, n-butyllithium (1.58 M hexane solution, 20.8 mL, 32.86 mmol) was slowly added dropwise and stirred at the same temperature for 10 min. Subsequently, 2-chloro-5-trifluoromethylpyridine (5.4616 g, 30.08 mmol) dissolved in anhydrous THF (30 mL) was added slowly dropwise at -78 °C and stirring was continued at the same temperature for 1 hour. Next, iodine (9.2188 g, 36.32 mmol) dissolved in anhydrous THF (30 mL) was added dropwise at -78 °C and stirred at the same temperature for 30 min before slowly warming to 0 °C. The reaction was quenched by the addition of 1 M aqueous sodium thiosulfate (50 mL) at 0 °C. The reaction was extracted three times with ethyl acetate, and the organic phases were combined and dried over anhydrous sodium sulfate. After removal of the solvent by distillation under reduced pressure, the resulting residue was purified by silica gel column chromatography (BW-200,80 g, eluent 30% benzene/hexane) to afford the target product 2-chloro-5-trifluoromethyl-4-iodopyridine (4.3977 g, 14.30 mmol, 48% yield). In addition, a white powdery product was obtained by recrystallization from EtOH.

References

[1] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[2] Patent: JP2016/700, 2016, A. Location in patent: Paragraph 0032
[3] Patent: WO2008/115369, 2008, A2. Location in patent: Page/Page column 50-51

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View Lastest Price from 2-chloro-5-(trifluoromethyl)-4-iodopyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

Career Henan Chemical Co

Product: 2-chloro-5-(trifluoromethyl)-4-iodopyridine 505084-55-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-07-01

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2-chloro-5-(trifluoromethyl)-4-iodopyridine ISO 9001：2015 REACH

CAS:505084-55-9

chloro-5-(trifluoromethyl)-4-iodopyridine

505084-55-9

Halides

Pyridines