methyl indoline-5-carboxylate
- Product Name
- methyl indoline-5-carboxylate
- CAS No.
- 141452-01-9
- Chemical Name
- methyl indoline-5-carboxylate
- Synonyms
- methyl indoline-5-carboxylate;Methyl 2,3-dihydro-1H-indole-5-carboxylate;2,3-Dihydro-1H-indol-5-carboxylic acid methyl ester;1H-Indole-5-carboxylicacid, 2,3-dihydro-, methyl ester
- CBNumber
- CB31094203
- Molecular Formula
- C10H11NO2
- Formula Weight
- 177.2
- MOL File
- 141452-01-9.mol
methyl indoline-5-carboxylate Property
- Melting point:
- 67-69 °C
- Boiling point:
- 331.0±31.0 °C(Predicted)
- Density
- 1.162±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 2.65±0.20(Predicted)
- color
- Off-White
- InChI
- InChI=1S/C10H11NO2/c1-13-10(12)8-2-3-9-7(6-8)4-5-11-9/h2-3,6,11H,4-5H2,1H3
- InChIKey
- VVAPQJBMJBCZMH-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(C(OC)=O)C=C2)CC1
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- M313618
- Product name
- Methylindoline-5-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M313618
- Product name
- Methylindoline-5-carboxylate
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- W3078
- Product name
- methylindoline-5-carboxylate
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 073567
- Product name
- Methyl indoline-5-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $217
- Updated
- 2021/12/16
- Product number
- 073567
- Product name
- Methyl indoline-5-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
methyl indoline-5-carboxylate Chemical Properties,Usage,Production
Synthesis
1011-65-0
141452-01-9
The general procedure for the synthesis of indoline-5-carboxylic acid methyl ester from indole-5-carboxylic acid was as follows: to a 10 mL solution of 1H-indole-5-carboxylic acid methyl ester (1 g, 5.71 mmol) in acetic acid was slowly added sodium cyano-borohydride (1.08 g, 17.18 mmol) at 0 °C, with the addition time being controlled to be within 5 minutes. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, water (3 mL) was added and all solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (150 mL) and saturated sodium bicarbonate solution (150 mL) for liquid-liquid separation. The aqueous phase was further extracted with ethyl acetate (3 x 75 mL). All organic phases were combined, washed with saturated saline (150 mL), dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-50% hexane solution of ethyl acetate containing 0.1% triethylamine) to afford the target product methyl indoline-5-carboxylate (0.99 g, 99% yield).
References
[1] Patent: WO2010/149685, 2010, A1. Location in patent: Page/Page column 51
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5684 - 5688
[3] Patent: US2015/368195, 2015, A1. Location in patent: Paragraph 0072
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 44, p. 8966 - 8976
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4425 - 4436
methyl indoline-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from methyl indoline-5-carboxylate manufacturers
- Product
- Methyl-indole-5-carboxylate in stock Factory 141452-01-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03
- Product
- methyl indoline-5-carboxylate 141452-01-9
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24