4-Bromo-2,6-diiodophenol
Uses- Product Name
- 4-Bromo-2,6-diiodophenol
- CAS No.
- 15459-51-5
- Chemical Name
- 4-Bromo-2,6-diiodophenol
- Synonyms
- Phenol,4-bromo-2,6-diiodo-
- CBNumber
- CB31106007
- Molecular Formula
- C6H3BrI2O
- Formula Weight
- 424.8
- MOL File
- 15459-51-5.mol
4-Bromo-2,6-diiodophenol Property
- storage temp.
- 2-8°C(protect from light)
- InChI
- InChI=1S/C6H3BrI2O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H
- InChIKey
- LFMOQCYPCSHKFH-UHFFFAOYSA-N
- SMILES
- C1(O)=C(I)C=C(Br)C=C1I
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B686973
- Product name
- 4-Bromo-2,6-diiodophenol
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0132604
- Product name
- 4-BROMO-2,6-DIIODOPHENOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.15
- Updated
- 2021/12/16
- Product number
- 6558CR
- Product name
- 4-Bromo-2,6-diiodophenol
- Packaging
- 25g
- Price
- $973
- Updated
- 2021/12/16
- Product number
- 15459515
- Product name
- 4-Bromo-2,6-diiodophenol
- Packaging
- 1g
- Price
- $1475.1
- Updated
- 2021/12/16
- Product number
- A393105
- Product name
- 4-Bromo-2,6-diiodophenol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $29
- Updated
- 2021/12/16
4-Bromo-2,6-diiodophenol Chemical Properties,Usage,Production
Uses
4-Bromo-2,6-diiodophenol is a phenolic derivative that can be used as an organic reagent.
Synthesis
106-41-2
15459-51-5
General method: Potassium iodide (2.1 eq.) was added to a 50% (v/v) aqueous solution under stirring conditions. Subsequently, a solution of acetic acid (AcOH, 1.0 M) containing 4-bromophenol (S5) and sodium percarbonate (SPC) (3.8 eq.) was slowly added over 30 min. The reaction mixture was stirred continuously at 50 °C for 2.0 h under a reflux condenser. After completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into a vigorously stirred two-phase mixture consisting of dichloromethane (CH2Cl2) and saturated aqueous sodium sulfite (Na2SO3) solution. The aqueous layer was separated and extracted twice with dichloromethane (CH2Cl2). The organic layers were combined and washed with saturated aqueous sodium chloride (NaCl). The organic layers were dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography to afford the target product 4-bromo-2,6-diiodophenol (23).
References
[1] Angewandte Chemie - International Edition, 2010, vol. 49, # 32, p. 5563 - 5566
[2] Tetrahedron, 2013, vol. 69, # 21, p. 4338 - 4352
[3] Tetrahedron Letters, 2006, vol. 47, # 28, p. 4793 - 4796
[4] Patent: WO2017/196081, 2017, A1. Location in patent: Paragraph 189; 190; 191; 192
[5] Helvetica Chimica Acta, 2011, vol. 94, # 12, p. 2248 - 2255
4-Bromo-2,6-diiodophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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