1-Bromo-3-iodobenzene
- Product Name
- 1-Bromo-3-iodobenzene
- CAS No.
- 591-18-4
- Chemical Name
- 1-Bromo-3-iodobenzene
- Synonyms
- 3-BROMOIODOBENZENE;3-bromoiodbenzene;m-Bromoiodobenzene;m-Iodobromobenzene;3-iodobroMobenzene;3- Bromiodobenzene;1-Brom-3-iodbenzol;3-Bromophenyl iodide;1-Bromo-3-iodobezene;3-BROMO-1-IODOBENZENE
- CBNumber
- CB7422232
- Molecular Formula
- C6H4BrI
- Formula Weight
- 282.9
- MOL File
- 591-18-4.mol
1-Bromo-3-iodobenzene Property
- Melting point:
- −9.3-−9 °C(lit.)
- Boiling point:
- 120 °C18 mm Hg(lit.)
- Density
- 2.219 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.66(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Oil
- color
- Colourless
- Specific Gravity
- 2.219
- Water Solubility
- insoluble
- Sensitive
- Light Sensitive
- BRN
- 1854384
- InChIKey
- CTPUUDQIXKUAMO-UHFFFAOYSA-N
- CAS DataBase Reference
- 591-18-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 3-Bromoiodobenzene(591-18-4)
- EPA Substance Registry System
- Benzene, 1-bromo-3-iodo- (591-18-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- T
- HazardClass
- IRRITANT, LIGHT SENSITIVE
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 280097
- Product name
- 3-Bromoiodobenzene
- Purity
- 98%
- Packaging
- 5g
- Price
- $18.75
- Updated
- 2025/07/31
- Product number
- 280097
- Product name
- 3-Bromoiodobenzene
- Purity
- 98%
- Packaging
- 25g
- Price
- $94.6
- Updated
- 2025/07/31
- Product number
- B1236
- Product name
- 1-Bromo-3-iodobenzene (stabilized with Copper chip)
- Packaging
- 5G
- Price
- $16
- Updated
- 2025/07/31
- Product number
- B1236
- Product name
- 1-Bromo-3-iodobenzene (stabilized with Copper chip)
- Packaging
- 25G
- Price
- $42
- Updated
- 2025/07/31
- Product number
- B1236
- Product name
- 1-Bromo-3-iodobenzene (stabilized with Copper chip)
- Packaging
- 100G
- Price
- $120
- Updated
- 2025/07/31
1-Bromo-3-iodobenzene Chemical Properties,Usage,Production
Chemical Properties
Clear colourless to light yellow liquid
Chemical Properties
Light sensitive. Incompatible with strong oxidizing agents, strong bases and strong acids. Store in a cool place.
Uses
1-Bromo-3-iodobenzene is used in the preparation of 3'-bromo-2,3,4,5,6-pentaethyl-biphenyl by reacting with hex-3-yne. It is also used to prepare 1-(3'-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3'-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene. Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.
Synthesis
585-76-2
591-18-4
Cesium carbonate (Cs2CO3, 0.6 mmol, 195 mg), m-bromobenzoic acid (1, 0.3 mmol), [Ir(dF(CF3)ppy]2(dtbbpy)]PF6 (D, 6 μmol, 6.7 mg), N-iodosuccinimide (NIS, 1.5 mmol, 337.5 mg) and iodine (I2, 60 μmol, 20 mol%). The tubes were evacuated and displaced three times with argon, followed by the addition of 3 mL of dry 1,2-dichloroethane (DCE) through a syringe under argon protection. The test tube was sealed with Parafilm? and placed in an oil bath equipped with a contact thermometer. The reaction system was irradiated with a 6 x 5 W blue LED lamp (λmax = 455 nm) at 50 °C for 24 to 36 hours. Upon completion of the reaction, the mixture was filtered through a 2 cm thick pad of silica gel and the silica gel was washed with dichloromethane (DCM, 50 mL). The filtrates were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography on silica gel to afford the target product 1-bromo-3-iodobenzene (2). (Note: The reaction is extremely sensitive to moisture, and the product yield was significantly reduced to less than 5% when 0.01 equivalents of water was added to the system.)
References
[1] Synlett, 2018, vol. 29, # 12, p. 1572 - 1577
[2] Patent: WO2015/68159, 2015, A2. Location in patent: Paragraph 00215-00216
1-Bromo-3-iodobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Bromo-3-iodobenzene manufacturers
- Product
- 1-Bromo-3-Iodobenzene 591-18-4
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-19
- Product
- 1-Bromo-3-iodobenzene 591-18-4
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- 1-Bromo-3-iodobenzene 591-18-4
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 2000KG
- Release date
- 2023-01-04