ChemicalBook > CAS DataBase List > 1-Bromo-3-iodobenzene

1-Bromo-3-iodobenzene

Product Name: 1-Bromo-3-iodobenzene
CAS No.: 591-18-4
Chemical Name: 1-Bromo-3-iodobenzene
Synonyms: 3-BROMOIODOBENZENE;3-bromoiodbenzene;m-Bromoiodobenzene;m-Iodobromobenzene;3-iodobroMobenzene;3- Bromiodobenzene;1-Brom-3-iodbenzol;3-Bromophenyl iodide;1-Bromo-3-iodobezene;3-BROMO-1-IODOBENZENE
CBNumber: CB7422232
Molecular Formula: C6H4BrI
Formula Weight: 282.9
MOL File: 591-18-4.mol

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1-Bromo-3-iodobenzene Property

Melting point:: −9.3-−9 °C(lit.)
Boiling point:: 120 °C18 mm Hg(lit.)
Density: 2.219 g/mL at 25 °C(lit.)
refractive index: n20/D 1.66(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: Oil
color: Colourless
Specific Gravity: 2.219
Water Solubility: insoluble
Sensitive: Light Sensitive
BRN: 1854384
InChIKey: CTPUUDQIXKUAMO-UHFFFAOYSA-N
CAS DataBase Reference: 591-18-4(CAS DataBase Reference)
NIST Chemistry Reference: 3-Bromoiodobenzene(591-18-4)
EPA Substance Registry System: Benzene, 1-bromo-3-iodo- (591-18-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25
WGK Germany: 3
Hazard Note: Irritant
TSCA: T
HazardClass: IRRITANT, LIGHT SENSITIVE
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 280097
Product name: 3-Bromoiodobenzene
Purity: 98%
Packaging: 5g
Price: $18.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: 280097
Product name: 3-Bromoiodobenzene
Purity: 98%
Packaging: 25g
Price: $94.6
Updated: 2025/07/31

TCI Chemical

Product number: B1236
Product name: 1-Bromo-3-iodobenzene (stabilized with Copper chip)
Packaging: 5G
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: B1236
Product name: 1-Bromo-3-iodobenzene (stabilized with Copper chip)
Packaging: 25G
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: B1236
Product name: 1-Bromo-3-iodobenzene (stabilized with Copper chip)
Packaging: 100G
Price: $120
Updated: 2025/07/31

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1-Bromo-3-iodobenzene Chemical Properties,Usage,Production

Chemical Properties

Clear colourless to light yellow liquid

Chemical Properties

Light sensitive. Incompatible with strong oxidizing agents, strong bases and strong acids. Store in a cool place.

Uses

1-Bromo-3-iodobenzene is used in the preparation of 3'-bromo-2,3,4,5,6-pentaethyl-biphenyl by reacting with hex-3-yne. It is also used to prepare 1-(3'-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3'-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene. Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Synthesis

585-76-2

591-18-4

Cesium carbonate (Cs2CO3, 0.6 mmol, 195 mg), m-bromobenzoic acid (1, 0.3 mmol), [Ir(dF(CF3)ppy]2(dtbbpy)]PF6 (D, 6 μmol, 6.7 mg), N-iodosuccinimide (NIS, 1.5 mmol, 337.5 mg) and iodine (I2, 60 μmol, 20 mol%). The tubes were evacuated and displaced three times with argon, followed by the addition of 3 mL of dry 1,2-dichloroethane (DCE) through a syringe under argon protection. The test tube was sealed with Parafilm? and placed in an oil bath equipped with a contact thermometer. The reaction system was irradiated with a 6 x 5 W blue LED lamp (λmax = 455 nm) at 50 °C for 24 to 36 hours. Upon completion of the reaction, the mixture was filtered through a 2 cm thick pad of silica gel and the silica gel was washed with dichloromethane (DCM, 50 mL). The filtrates were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography on silica gel to afford the target product 1-bromo-3-iodobenzene (2). (Note: The reaction is extremely sensitive to moisture, and the product yield was significantly reduced to less than 5% when 0.01 equivalents of water was added to the system.)

References

[1] Synlett, 2018, vol. 29, # 12, p. 1572 - 1577
[2] Patent: WO2015/68159, 2015, A2. Location in patent: Paragraph 00215-00216

1-Bromo-3-iodobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Bromo-3-iodobenzene manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1-Bromo-3-Iodobenzene 591-18-4
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-19

Hebei Chuanghai Biotechnology Co,.LTD

Product: 1-Bromo-3-iodobenzene 591-18-4
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Kindchem(Nanjing)Co.,Ltd

Product: 1-Bromo-3-iodobenzene 591-18-4
Price: US $0.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 2000KG
Release date: 2023-01-04

591-18-4, 1-Bromo-3-iodobenzeneRelated Search:

4-Iodoanisole (Diacetoxyiodo)benzene Iodobenzene 1,4-Diiodobenzene 3-Bromobenzyl alcohol 3-Nitrobenzyl bromide (3-NITROPHENYL)ACETIC ACID METHYL ESTER 3-Bromoanisole 3-Nitroacetophenone 3-Bromobenzyl bromide 3-Nitrobenzaldehyde 3-Bromobenzonitrile 3-Bromobenzaldehyde Bromine 1-Bromo-4-iodobenzene, 97+%,1-Bromo-4-iodobenzene,98%,1-Bromo-4-Iodobenzene>99%,1-BROMO-4-IODOBENZENE,4-BROMO-1-IODOBENZENE 3-BROMO-5-IODOBENZOIC ACID 5-BROMO-2-IODOBENZONITRILE 5-BROMO-2-IODOBENZALDEHYDE

Benzene, 1-bromo-3-iodo-

m-Bromoiodobenzene

1-BROMO-3-IODOBENZENE

3-BROMOIODOBENZENE

3-Bromoiodobenzene m-Bromoiodobenzene

1-Bromo-3-iodobenzene,98%

3-bromoiodbenzene

3-BROMO-1-IODOBENZENE

1-Bromo-3-iodobenzene (stabilized with Copper chip)

3-Bromophenyl iodide

m-Iodobromobenzene

1-BroMo-3-iodobenzene, 98+% 10ML

3-iodobroMobenzene

3-BroMoiodobenzene 98%

3-BroMoiodobenzene, 97+%

3 - broMine iodobenzene

Inter-bromo-iodobenzene

1-bromo-3-iodo-benzen

1-Bromo-3-iodobezene

Vortioxetine Impurity 54

1-Bromo-3-iodobenzene (stabilized with Copper chip)&gt

3- Bromiodobenzene

1-Brom-3-iodbenzol

1-Bromo-3-iodobenzene ISO 9001：2015 REACH

591-18-4

591-19-4

C8H4BrI

HALOGEN

Aryl

Building Blocks

Halogenated Hydrocarbons

Organic Building Blocks

Organohalides

Aromatic Hydrocarbons (substituted) & Derivatives

API intermediates

Miscellaneous

Bromine Compounds

Iodine Compounds

Aryl

Halogenated Hydrocarbons

bc0001

591-18-4