5-Aminothiazole-4-carboxylic acid ethyl ester
- Product Name
- 5-Aminothiazole-4-carboxylic acid ethyl ester
- CAS No.
- 18903-18-9
- Chemical Name
- 5-Aminothiazole-4-carboxylic acid ethyl ester
- Synonyms
- Ethyl 5-aminothiazole-4-carboxylate;2-Pyrrolidinone,6-(hydroxymethyl)-;Ethyl 5-aMino-1,3-thiazole-4-carboxylate;5-Aminothiazole-4-carboxylic acid ethyl ester;4-Thiazolecarboxylic acid, 5-aMino-, ethyl ester;ethyl 5-aminothiazole-4-carboxylate hydrochloride
- CBNumber
- CB31113317
- Molecular Formula
- C6H8N2O2S
- Formula Weight
- 172.2
- MOL File
- 18903-18-9.mol
5-Aminothiazole-4-carboxylic acid ethyl ester Property
- Melting point:
- 163.5 °C
- Boiling point:
- 300.7±22.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.67±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E939903
- Product name
- Ethyl5-aminothiazole-4-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 9849AA
- Product name
- Ethyl5-aminothiazole-4-carboxylate
- Packaging
- 250mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CHM0384542
- Product name
- ETHYL-5-AMINOTHIAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.05
- Updated
- 2021/12/16
- Product number
- 135414
- Product name
- Ethyl 5-amino-1,3-thiazole-4-carboxylate
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $1565
- Updated
- 2021/12/16
- Product number
- 135414
- Product name
- Ethyl 5-amino-1,3-thiazole-4-carboxylate
- Purity
- 95%+
- Packaging
- 5g
- Price
- $2360
- Updated
- 2021/12/16
5-Aminothiazole-4-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron, 41, p. 5989, 1985 DOI: 10.1016/S0040-4020(01)91439-5
Synthesis
1759-25-7
18903-18-9
Synthesis of compound 16c: Preparation of ethyl 5-aminothiazole-4-carboxylate: compound 16b (9.0 g, 58 mmol) was suspended in toluene (200 ml). Lawesson's reagent (23.0 g, 58 mmol, 1 eq.) was added at once. The resulting yellow suspension was stirred overnight at 70 °C and under N2 atmosphere. Upon completion of the reaction, the mixture was cooled to 0°C and the toluene layer was poured from the colloidal material at the bottom of the flask and washed with aqueous 1N hydrochloric acid (6 x 50 ml). The colloidal material was dissolved in methanol (150 ml) and subsequently concentrated under reduced pressure. The residue (brown oily substance) was suspended in tert-butyl methyl ether (TBME, 300 ml) and washed with 1N aqueous hydrochloric acid (1 x 300 ml, 2 x 100 ml). The aqueous portions were combined and alkalized with 2N aqueous sodium hydroxide (460 ml) followed by extraction with ethyl acetate (EtOAc, 1 x 300 ml, 2 x 200 ml and 1 x 100 ml). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product ethyl 5-aminothiazole-4-carboxylate (7 g). The crude product was purified by column chromatography (silica gel, heptane-ethyl acetate, 1/1) to afford compound 16c (6 g, 35 mmol, 60% yield) as a brown solid.1H-NMR (300 MHz, CDCl3) δ 7.89 (s, 1H), 6.04 (bs, 2H), 4.42 (q, 2H, J=7Hz), 1.43 (t, 3H) J=7Hz).
References
[1] Patent: WO2008/59368, 2008, A2. Location in patent: Page/Page column 66-68
[2] Patent: WO2014/33630, 2014, A1. Location in patent: Page/Page column 50
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3774 - 3780
[4] Nucleosides and Nucleotides, 1995, vol. 14, # 3-5, p. 313 - 316
[5] Chemical and Pharmaceutical Bulletin, 1971, vol. 19, p. 119 - 123
5-Aminothiazole-4-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Aminothiazole-4-carboxylic acid ethyl ester manufacturers
- Product
- JANUS BLACK 18903-18-9
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-17