1-(Diphenylmethyl)-3-azetidinyl methanesulfonate

Product Name: 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate
CAS No.: 33301-41-6
Chemical Name: 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate
Synonyms: 1-BENZHYDRYLAZETIDIN-3-YL METHANESULFONATE;BUTTPARK 37\04-14;1-BENZHYDRYL-3-METHANESULFONATOAZETIDINE;1-(Diphenylmethyl)-3-(mesyloxy)azetidine;1-Benzhydryl-3-azetidinyl methanesulfonate;1-BENZHYDRYL-3-METHANESULFONYLOXY AZETIDINE;1-Benzhydryl-3-methanesulphonyloxyazetidine;1-BENZHYDRYL-3-METHANESULFONATOAZETIDINE 98%;1-Benzhydryl-3-azetidinylMethanesulfonate>1-BENZHYDRYL-3-METHANESULFONATOAZETIDINE CAS
CBNumber: CB3111828
Molecular Formula: C17H19NO3S
Formula Weight: 317.4
MOL File: 33301-41-6.mol

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1-(Diphenylmethyl)-3-azetidinyl methanesulfonate Property

Melting point:: 111-112°C
Boiling point:: 459.9±34.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
form: Solid
pka: 5.67±0.10(Predicted)
color: White
InChI: InChI=1S/C17H19NO3S/c1-22(19,20)21-16-12-18(13-16)17(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16-17H,12-13H2,1H3
InChIKey: MSVZMUILYMLJCF-UHFFFAOYSA-N
SMILES: N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(OS(C)(=O)=O)C1
CAS DataBase Reference: 33301-41-6(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S906700
Product name: 1-(DIPHENYLMETHYL)-3-AZETIDINYL METHANESULFONATE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: S906700
Product name: 1-(DIPHENYLMETHYL)-3-AZETIDINYL METHANESULFONATE
Purity: Aldrich
Packaging: 50mg
Price: $29.8
Updated: 2024/03/01

TCI Chemical

Product number: D4131
Product name: 1-Benzhydryl-3-azetidinyl Methanesulfonate
Purity: >95.0%(HPLC)(T)
Packaging: 1g
Price: $205
Updated: 2023/06/20

TRC

Product number: B196875
Product name: 1-Benzhydryl-3-methanesulfonatoazetidine
Packaging: 10g
Price: $45
Updated: 2021/12/16

Usbiological

Product number: B1060-81
Product name: 1-Benzhydryl-3-methanesulfonatoazetidine
Packaging: 1g
Price: $403
Updated: 2021/12/16

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1-(Diphenylmethyl)-3-azetidinyl methanesulfonate Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

A proline analog and proline formation inhibitor

Synthesis

Preparation procedure of 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate: To a reaction flask was charged 632 g (2.64 mol) of 1-benzhydrylazetidin- 3-ol, acetonitrile (1.9 L), and triethylamine (601 g, 1.5 equiv). The mixture was cooled in an ice-acetone bath (-5 °C). Methanesulfonyl chloride (436 g, 1.20 equiv) was added via a drop funnel while keeping the reaction temperature at less than5 °C. HPLC showed reaction completion after 15 min. Water (6.3 L) was added, and the reaction mixture was stirred for 2 h at room temperature and filtered. The filter cake was rinsed with water (2 x 1 L), pulled dry under vacuum, and directly subjected to the amination reaction in the next step. Yield 100%.

References

[1] Patent: US2005/54697, 2005, A1. Location in patent: Page/Page column 78
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 4, p. 1084 - 1088
[3] Patent: WO2011/61214, 2011, A1. Location in patent: Page/Page column 85-86
[4] Patent: US2014/288045, 2014, A1. Location in patent: Paragraph 0605
[5] Patent: WO2016/44772, 2016, A1. Location in patent: Paragraph 319

1-(Diphenylmethyl)-3-azetidinyl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(Diphenylmethyl)-3-azetidinyl methanesulfonate Suppliers

Americas 1 Belgium 1 Canada 3 China 179 Europe 1 Germany 5 India 13 Japan 3 United Kingdom 10 United States 36 Global 252

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Energy Chemical

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View Lastest Price from 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate 33301-41-6
Price: US $31.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate 33301-41-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(Diphenylmethyl)-3-azetidinyl methanesulfonate 33301-41-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

33301-41-6, 1-(Diphenylmethyl)-3-azetidinyl methanesulfonateRelated Search:

Methanesulfonic acid Methyl acrylate N-Methyl-2-pyrrolidone 2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT Ethyl methanesulfonate Dimethyl succinate BUTYL OLEATE Gabexate mesylate Dimethyl sulfone Hexamethyldisilazane Methyl propiolate p-Toluenesulfonic acid TRIMETHYLENE OXIDE Tris(trimethylsilyl)phosphate Octadecyl methacrylate Tris(hydroxymethyl)aminomethane Formaldehyde sodium bisulfite Poly(methyl methacrylate)

BUTTPARK 37\04-14

1-BENZHYDRYL-3-METHANESULFONATOAZETIDINE

1-BENZHYDRYL-3-METHANESULFONYLOXY AZETIDINE

1-BENZHYDRYLAZETIDIN-3-YL METHANESULFONATE

1-(DIPHENYLMETHYL)-3-(METHANESULFONYLOXY)AZETIDINE

1-DIPHENYLMETHYL-3-AZETIDINYL METHANESULFONATE

1-(diphenylmethyl)-3-(methanesulfonyloxy)azetinide

1-Diphenylmethyl-3-azetidinyl Methanethiosulfonate

1-Benzhydryl-3-methanesulphonyloxyazetidine

1-BENZHYDRYL-3-METHANESULFONATOAZETIDINE 98%

Methanesulfonic acid 1-benzhydryl-azetidin-3-yl ester

1-(Diphenylmethyl)-3-(mesyloxy)azetidine

1-(Diphenylmethyl)-3-[(methylsulfonyl)oxy]azetidine

1-(Diphenylmethyl)azetidin-3-yl methanesulfonate

1-Benzhydryl-3-azetidinyl Methanesulfonate, 95%

methanesulfonic acid [1-[di(phenyl)methyl]-3-azetidinyl] ester

1-Benzhydrylazetidin-3-yl methanesulfonate 97%

methanesulfonic acid [1-[di(phenyl)methyl]azetidin-3-yl] ester

(1-benzhydryl-2-hydroxyazetidin-3-yl)methanesulfonate

1-(Diphenylmethyl)-3-azetidinyl methanesulfonate 95%

1-(Diphenylmethyl)-3-azetidinyl methanesulfote

1-Benzhydryl-3-azetidinylMethanesulfonate&gt

3-Azetidinol, 1-(diphenylmethyl)-, 3-methanesulfonate

1-BENZHYDRYL-3-METHANESULFONATOAZETIDINE CAS

1-(Diphenylmethyl) azitidine-3-yl methane sulfonate

Methane Sulphonic acid 1-Bezhydryl Azetidine 3-yl Ester

1-Benzhydrylazetidin-3-yl methanesulfonate - [B5254]

1-Benzhydryl-3-azetidinyl methanesulfonate

33301-41-6

3301-41-6

C17H19NO3S

Aromatics

Heterocycles

MTS & Sulfhydryl Active Reagents