2,3-DIBROMOQUINOLINE
Application- Product Name
- 2,3-DIBROMOQUINOLINE
- CAS No.
- 13721-00-1
- Chemical Name
- 2,3-DIBROMOQUINOLINE
- Synonyms
- 2,3-DIBROMOQUINOLINE;Quinoline, 2,3-dibromo-
- CBNumber
- CB3113448
- Molecular Formula
- C9H5Br2N
- Formula Weight
- 286.95
- MOL File
- 13721-00-1.mol
2,3-DIBROMOQUINOLINE Property
- Melting point:
- 77 °C
- Boiling point:
- 332.5±22.0 °C(Predicted)
- Density
- 1.923±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.97±0.50(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D426135
- Product name
- 2,3-Dibromoquinoline
- Packaging
- 25mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- X9974
- Product name
- 2,3-Dibromoquinoline
- Packaging
- 250mg
- Price
- $224
- Updated
- 2021/12/16
- Product number
- FD31084
- Product name
- 2,3-Dibromoquinoline
- Packaging
- 250mg
- Price
- $262.5
- Updated
- 2021/12/16
- Product number
- FD31084
- Product name
- 2,3-Dibromoquinoline
- Packaging
- 500mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- FD31084
- Product name
- 2,3-Dibromoquinoline
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
2,3-DIBROMOQUINOLINE Chemical Properties,Usage,Production
Application
2,3-Dibromoquinoline is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Synthesis
5332-24-1
13721-00-1
General procedure for the synthesis of 2,3-dibromoquinoline from 3-bromoquinoline: To a stirred solution of 3-bromoquinoline (306 mg, 1.47 mmol) in dichloromethane (3 mL) was added m-chloroperoxybenzoic acid (m-CPBA, 358 mg, 85% max, 1.76 mmol) at 0 °C and the reaction was stirred overnight at room temperature. Additional dichloromethane (11.6 mL) was added to the reaction mixture. Phosphorus tribromide oxide (POBr3, 516 mg, 1.76 mmol) was added to the resulting solution at 0 °C, followed by dropwise addition of N,N-dimethylformamide (DMF, 57 μL, 0.74 mmol) under argon protection. The reaction mixture was gradually warmed to 25 °C and stirred for 2 h, after which additional dichloromethane (10 mL) was added. Saturated aqueous sodium carbonate solution was slowly added to the reaction mixture and the pH was adjusted to 7-8. The resulting mixture was separated and the aqueous phase was thoroughly extracted with dichloromethane. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (petroleum ether: ethyl acetate = 100:1) to afford 2,3-dibromoquinoline (335 mg, 79% yield) as a white solid.
References
[1] Tetrahedron, 2016, vol. 72, # 38, p. 5762 - 5768
[2] Organic Letters, 2007, vol. 9, # 26, p. 5525 - 5528
2,3-DIBROMOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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