1H-indazole-6-carboxylic acid
- Product Name
- 1H-indazole-6-carboxylic acid
- CAS No.
- 704-91-6
- Chemical Name
- 1H-indazole-6-carboxylic acid
- Synonyms
- 6-Carboxy-1H-indazole;INDAZOLE-6-CARBOXYLIC ACID;1H-Indazole-6-carboylic acid;1H-Indazol-6-carboxylic acid;1-H-indazole-6-carboxyle acid;1H-INDAZOLE-6-CARBOXYLIC ACID;6-(1H)INDAZOLE CARBOXYLIC ACID;1H-Indazole-6-carboxylic acid 97%;1H-Indazole-6-carboxylic acid, 97%+;1H-Indazole-6-carboxylic acid (7CI, 8CI, 9CI, ACI)
- CBNumber
- CB3113514
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 704-91-6.mol
1H-indazole-6-carboxylic acid Property
- Melting point:
- 302-307 °C
- Boiling point:
- 443.7±18.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.01±0.30(Predicted)
- form
- Crystalline Powder
- color
- White to light brown
- InChIKey
- DNCVTVVLMRHJCJ-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 702420
- Product name
- 1H-Indazole-6-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $110
- Updated
- 2023/06/20
- Product number
- I509000
- Product name
- 1H-Indazole-6-carboxylic acid
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 053791
- Product name
- 1H-Indazole-6-carboxylic acid
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- OR60063
- Product name
- 1H-Indazole-6-carboxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4H21-1-D0
- Product name
- 1H-Indazole-6-carboxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
1H-indazole-6-carboxylic acid Chemical Properties,Usage,Production
Uses
1H-Indazole-6-carboxylic Acid is used as a reagent to synthesize azabicyclic aryl amides, which act as α7 nicotinic acetylcholine receptor agonists.
Preparation
Synthesis of 1H-indazole-6-carboxylic acid, H2L3: MeL3Ac (1.0 g; 4.6 mmol) was dissolved in 40 mL THF, and this solution was added to a 40 mL aqueous solution of lithium hydroxide (5.0 g; 210 mmol). The resulting suspension was heated at reflux with vigorous stirring overnight, after which time the solution was concentrated under vacuum to remove the organic phase. The resulting solution was filtered, adjusted to pH 3 with conc. HCl, to precipitate the product as a pale brown solid, which was filtered, washed with water and dried under vacuum. Yield 315 mg, 43%. mp 292–296 °C (decomp);
δH (500 MHz, d6-DMSO): 7.67 (dd, 1H, J = 8.3, 1.0 Hz, H4 ), 7.85 (dd, 1H, J = 8.3, 0.8 Hz, H3 ), 8.15 (s, 1H, H6 ), 8.18 (d, 1H, J = 0.8 Hz, H2 ), 13.24 (br s, 2H, H1 & H5 ); δC (125 MHz, CD3OD): 114.1, 122.0, 122.6, 127.1, 130.6, 135.2, 141.4, 170.4; HRMS-ESI m/z: found: 163.0503; C8H7N2O2 requires: 163.0502 [M + H+ ]; ˉνmax/cm?1 (KBr): 3258 br, 2864 br, 2582 br, 1679 s, 1579 m, 1518 m, 1425 m, 1230 s, 1087 m, 954 s, 857 m, 762 m, 693 m.
1H-indazole-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-indazole-6-carboxylic acid manufacturers
- Product
- 1H-Indazole-6-carboxylic acid 704-91-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1H-INDAZOLE-6-CARBOXYLIC ACID 704-91-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09