N-(2-HYDROXYETHYL)NITOTINAMIDE
- Product Name
- N-(2-HYDROXYETHYL)NITOTINAMIDE
- CAS No.
- 6265-73-2
- Chemical Name
- N-(2-HYDROXYETHYL)NITOTINAMIDE
- Synonyms
- SG-86;Nicorandil Impurity 1;Nicorandil EP Impurity B;Hydroxyethylnicotinamide;Nicorandil EP Impurity 2;N-(2-hydroxyethyl)nicotinamide;N-(2-HYDROXYETHYL)NITOTINAMIDE;N-(2-hydroxyethyl)pyridine-3-carboxamide;N-(2-Hydroxyethyl)-3-Pyridine Carboxamide;3-Pyridinecarboxamide,N-(2-hydroxyethyl)-
- CBNumber
- CB31177348
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 6265-73-2.mol
N-(2-HYDROXYETHYL)NITOTINAMIDE Property
- Melting point:
- 92 °C
- Boiling point:
- 185-195 °C(Press: 0.4-0.6 Torr)
- Density
- 1.212±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 12.94±0.46(Predicted)
- color
- White to Pale Yellow
- InChI
- InChI=1S/C8H10N2O2/c11-5-4-10-8(12)7-2-1-3-9-6-7/h1-3,6,11H,4-5H2,(H,10,12)
- InChIKey
- SJZLOWYUGKIWAK-UHFFFAOYSA-N
- SMILES
- C1=NC=CC=C1C(NCCO)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- EME00383
- Product name
- <I>N</I>-(2-Hydroxyethyl)pyridine-3-carboxamide
- Packaging
- 1 g
- Price
- $569
- Updated
- 2025/07/31
- Product number
- H942365
- Product name
- N-(2-Hydroxyethyl)nicotinamide
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- W7469
- Product name
- N-(2-HYDROXYETHYL)NITOTINAMIDE
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 074603
- Product name
- N-(2-Hydroxyethyl)nitotinamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $278
- Updated
- 2021/12/16
- Product number
- CHM0312000
- Product name
- N-(2-HYDROXYETHYL)-3-PYRIDINECARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.61
- Updated
- 2021/12/16
N-(2-HYDROXYETHYL)NITOTINAMIDE Chemical Properties,Usage,Production
Uses
N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.
Synthesis
59-67-6
141-43-5
6265-73-2
The general procedure for the synthesis of N-(2-hydroxyethyl)-3-pyridinecarboxamide from nicotinic acid and 2-aminoethanol was as follows: suspension of nicotinic acid (0.385 g, 3.13 mmol) in anhydrous toluene (15 mL), addition of thionyl chloride (455 μL, 6.26 mmol), and refluxing of the reaction mixture for 4 hours at 140 °C. After cooling, a clarified solution was obtained and the solvent was removed in vacuum. The solid residue was washed three times with ether, followed by the addition of fresh anhydrous toluene (15 mL) and ethanolamine (756 μL, 12.52 mmol). The mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed under vacuum and the solid residue was purified by silica gel column chromatography using dichloromethane/methanol (9.2:0.8) as eluent. The final white solid product N-(2-hydroxyethyl)-3-pyridinecarboxamide (450 mg, 86% yield) was obtained with a melting point of 205 °C. The 1H NMR (300 MHz, DMSO-d6) data of the product were as follows: δ 9.00 (s, 1H, NH), 8.68 (m, 2H, Ar-H), 8.17 (d, 1H, Ar-H), 7.60 (m, 1H, Ar-H), 4.74 (m, 1H, OH), 3.51 (m, 2H, CH2), 3.36 (m, 2H CH2).
References
[1] Patent: WO2006/92204, 2006, A1. Location in patent: Page/Page column 16-17
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5134 - 5147
[3] Archiv der Pharmazie, 2003, vol. 336, # 10, p. 445 - 455
N-(2-HYDROXYETHYL)NITOTINAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(2-HYDROXYETHYL)NITOTINAMIDE manufacturers
- Product
- N-(2-Hydroxyethyl)Nitotinamide 6265-73-2
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-17
- Product
- N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- N-(2-HYDROXYETHYL)NITOTINAMIDE 6265-73-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13