(S)-3-Aminobutan-1ol
- Product Name
- (S)-3-Aminobutan-1ol
- CAS No.
- 61477-39-2
- Chemical Name
- (S)-3-Aminobutan-1ol
- Synonyms
- (S)-3-Aminobutan-1ol;(S)-3-Amin-1-butanol;(S)-3-Aminopropan-1-ol;(3S)-3-Amino-1-butanol;(3S)-3-aminobutan-1-ol;(+)-(S)-3-aMinopropan-1-ol;1-Butanol, 3-amino-, (3S)-;(S)-3-Aminobutan-1-ol - [A10771];1-Fmoc-4-(Cbz-amino)piperidine-4-carboxylic acid
- CBNumber
- CB31180140
- Molecular Formula
- C4H11NO
- Formula Weight
- 89.14
- MOL File
- 61477-39-2.mol
(S)-3-Aminobutan-1ol Property
- Boiling point:
- 168℃
- Density
- 0.927
- Flash point:
- 56℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Ethanol (Sparingly). Methanol (Slightly)
- form
- Oil
- pka
- 15.00±0.10(Predicted)
- color
- Colourless to Light Yellow
- optical activity
- Consistent with structure
Safety
- RIDADR
- 2735
- HazardClass
- 8
- PackingGroup
- Ⅲ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A601888
- Product name
- (S)-3-Aminobutan-1-ol
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- A601888
- Product name
- (S)-3-Aminobutan-1-ol
- Packaging
- 5g
- Price
- $670
- Updated
- 2021/12/16
- Product number
- A10771
- Product name
- (S)-3-Aminobutan-1-ol
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- A10771
- Product name
- (S)-3-Aminobutan-1-ol
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FA141981
- Product name
- (S)-3-Aminobutan-1-ol
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
(S)-3-Aminobutan-1ol Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
(S)-3-Aminobutan-1-ol can be used as an intermediate in the preparation of compounds having HIV integrase inhibitory activity.
Synthesis
168827-91-6
61477-39-2
General procedure for the synthesis of (S)-3-aminobutanol from (S)-benzyl(4-hydroxybutan-2-yl)carbamate: To a 1000 mL round bottom flask was added a solution of (S)-benzyl(4-hydroxybutan-2-yl)carbamate (30 g, 134.4 mmol, 1.00 eq.) in methanol (500 mL), followed by the addition of palladium carbon (3 g, 0.10 equivalent). The reaction mixture was stirred at 25 °C for 12 h under hydrogen atmosphere. Upon completion of the reaction, the solid catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 11.7 g (92% yield) of (S)-3-aminobutan-1-ol as a colorless oil. The product was confirmed by 1H NMR (300 MHz, DMSO-d6, ppm): δ 4.48 (3H, s), 3.47 (2H, s), 2.96 (1H, s), 1.47-1.41 (2H, q), 1.02-0.99 (3H, d); the LCMS (ESI) analysis showed a m/z of 90 [M + H]+; the specific spectroscopy measurement value of [α]D22 +11.65° (c = 1.22 g/100 mL in EtOH) is consistent with the literature value of [α]D20 +16.3° (c = 4.5 in EtOH) (J. Org. Chem. 1996, 61, 2293-2304).
References
[1] Patent: WO2014/9447, 2014, A1. Location in patent: Page/Page column 96; 97
[2] Patent: WO2014/202741, 2014, A1. Location in patent: Page/Page column 42; 43
[3] Patent: US2015/197529, 2015, A1. Location in patent: Paragraph 1201; 1204
[4] Patent: US2016/168141, 2016, A1. Location in patent: Paragraph 1210; 1213
[5] Patent: WO2016/96936, 2016, A1. Location in patent: Page/Page column 43
(S)-3-Aminobutan-1ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-3-Aminobutan-1ol manufacturers
- Product
- (S)-3-Aminobutan-1ol 61477-39-2
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-08