ChemicalBook > CAS DataBase List > 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Product Name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS No.
762240-92-6
Chemical Name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
Synonyms
Sitagliptin hydrochloride;3-(trifluoromethyl)-5,6,7,8-tetrahydro;Sitagliptin Triazole Hydrochloride;3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3-;3-(Trifluoromethyl)-5;Sitagliptin interMediate A;3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride;3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch;5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride;5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98%
CBNumber
CB31228965
Molecular Formula
C6H7F3N4.ClH
Formula Weight
228.6
MOL File
762240-92-6.mol
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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Property

Melting point:
236-246°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C6H7F3N4.ClH/c7-6(8,9)5-12-11-4-3-10-1-2-13(4)5;/h10H,1-3H2;1H
InChIKey
AQCSCRYRCRORET-UHFFFAOYSA-N
SMILES
C12=NN=C(C(F)(F)F)N1CCNC2.[H]Cl
CAS DataBase Reference
762240-92-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN2811
HS Code 
2933599577
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T2998
Product name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
1g
Price
$60
Updated
2024/03/01
TCI Chemical
Product number
T2998
Product name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
5g
Price
$176
Updated
2024/03/01
Alfa Aesar
Product number
H64993
Product name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine hydrochloride, 98+%
Packaging
1g
Price
$89.3
Updated
2024/03/01
Alfa Aesar
Product number
H64993
Product name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine hydrochloride, 98+%
Packaging
5g
Price
$390
Updated
2024/03/01
TRC
Product number
T791810
Product name
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride
Packaging
500mg
Price
$65
Updated
2021/12/16
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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Chemical Properties,Usage,Production

Description

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a pharmaceutical intermediate compound used in the preparation of Sitagliptin phosphate. Sitagliptin is an oral hypoglycaemic agent, a dipeptidyl peptidase-4 inhibitor, which is used in the treatment of type 2 diabetes.

Chemical Properties

White Solid or White to Light yellow powder to crystal

Uses

Sitagliptin intermediate.

Synthesis

A suspension of N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide (27.3 g, 0.13 mol) in 110 mL of methanol was WARMED TO 55 ℃. 37% Hydrochloric acid (11.2 mL, 0.14 mol) was added over 15 min at this temperature. During the addition, all solids dissolved, resulting in a clear solution. The reaction was aged for 30 min. The solution was cooled to 20 ℃ and aged at this temperature until a seed bed formed (10 min to 1 h). 300 ML of MTBE was charged at 20 ℃ over 1 h. The resulting slurry was cooled to 2 ℃, aged for 30 min and filtered. Solids were washed with 50 mL of ethanol: MTBE (1: 3) and dried under vacuum at 45 ℃. Yield of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride was 26.7 g (99.5 area wt% pure by HPLC).

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Suppliers

Canada 1 China 510 India 64 Japan 1 Switzerland 1 United Kingdom 2 United States 26 Global 605
Carbosynth
Tel
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Fax
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
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Fax
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Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
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View Lastest Price from 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride manufacturers

Nanjing Fred Technology Co., Ltd
Product
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
97.5%-101.0%
Supply Ability
10 TONS
Release date
2021-06-24
Hebei Yanxi Chemical Co., Ltd.
Product
MALONALDEHYDE DIANILIDE HYDROCHLORIDE 762240-92-6
Price
US $20.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20mt/mon
Release date
2023-09-05

762240-92-6, 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochlorideRelated Search:

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (+/-)1-(1-Naphthyl)ethylamine Sitagliptin Impurity 27 Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- Sitagliptin N-Sulfate Sitagliptin Defuoro IMpurity 4 Sitagliptin Impurity 26 Meldrum's Acid Fenasi Sitagliptin phosphate Prazosin 2-Methylpyrazine Terazosin hydrochloride Terazosin Doxazosin Tetramethylpyrazine Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-

  • 3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3-
  • 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride
  • Sitagliptin Triazole Hydrochloride
  • Sitagliptin Impurity 64
  • 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98%
  • Sitagliptin interMediate A
  • 1,2,4-Triazolo[4,3-a]pyrazine,5,6,7,8-tetrahydro-3-(trifluoroMethyl)-,hydrochloride(1:1)
  • 3 - (three fluorinated Methyl) - 5,6,7,8 - four hydrogen - triazole 4-trichlorobenzene [1] and [4, 3 - alpha] pyrazine hydrochloride
  • 3-(Trifluoromethyl)-5,6,7,8-tetra-hydro-[1,2,4]-Triazolo-[4,3-a]-pyrazine hydrochloride Salt
  • Sitagliptin side chain
  • 5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride
  • Sitagliptin Intermediates Impurity
  • 3-CF3-5,6,7,8-H4-[1,2,4]triazolo[4,3a]pyrazine HCl
  • Triazolepine hydrochloride
  • 3-(Trifluoromethyl)-5
  • 3-a]pyrazine hydrochloride
  • Sitagliptin Impurity 20 HCl
  • 3-(trifluoromethyl)-5,6,7,8-r
  • Sitagliptin Triazole Impurity HCl
  • 3-(trifluoromethyl)-5,6,7,8-tetrahydro
  • Sitagliptin-16
  • 3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch
  • Sitagliptin Triazole (Impurity C)
  • Sitaglliptin phosphate intermediate
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine Hydrochloride
  • 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine Monohydrochloride
  • 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Monohydrochloride
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochlorid
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
  • 3-(trifluoromethyl)-5,6,7,8-retrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazine HCl
  • 3-(TrifluoroMethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyr
  • 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
  • 3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
  • 5,8-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
  • Sitagliptin Intermediate 2
  • 1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(trifluoroMethyl)-, hydrochloride
  • Sitagliptin hydrochloride
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride （Sitagliptin）
  • Sitagliptin triazole impurity hydrochloride
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a]pyrazine hydrochloride [TTTP]
  • pyrazine HCl
  • Cas762240-92-6 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine Hydrochloride
  • Sitagliptin Impurity 20 Hydrochloride
  • Urgent?
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride ISO 9001：2015 REACH
  • 3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazolio [4,3-a] pyrazine
  • 3-(terifluoromethyl)-7-[(2,4,5-trifluorophenyl]acetyl]-5,6,7,8- tetrahydro[1,2,4]triazole[4,3-a]pyrazine
  • Sitagliptin Triazole HCL
  • 3-trifluoro methyl-[1,2,4]triazole[4,3-a]piperazine hydrochl...
  • 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride / Sitagliptin Intermediate
  • SitagliptinImpurity20-d4
  • 4-(Trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4] Triazolo[4,3-a]pyrazine Hydrochloride
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride,[1,2,4]Triazolo[4,3-a]Pyrazine Hydrochloride 762240-92-6 Sitagliptin
  • 3-(Trifluoromethyl)-5,6,7,8-tetrahydro- triazolopyrazine Hydrochloride (Triazole)
  • 3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIZOLO[4,3-A]PYRAZINE HYDROCHLORIDE
  • 3- (Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2.41 triazolo[4,3-a] pyrazine hydrochloride,TRIAZOLE
  • 3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazole and [4,3-a] pyrazine hydrochloride