Senicapoc
- Product Name
- Senicapoc
- CAS No.
- 289656-45-7
- Chemical Name
- Senicapoc
- Synonyms
- Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
- CBNumber
- CB31261049
- Molecular Formula
- C20H15F2NO
- Formula Weight
- 323.34
- MOL File
- 289656-45-7.mol
Senicapoc Property
- Melting point:
- 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
- Boiling point:
- 460.7±45.0 °C(Predicted)
- Density
- 1.250±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
- form
- Powder
- pka
- 15.41±0.50(Predicted)
- color
- White to yellow
- InChI
- InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
- InChIKey
- SCTZUZTYRMOMKT-UHFFFAOYSA-N
- SMILES
- C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N
N-Bromosuccinimide Price
- Product number
- 29679
- Product name
- Senicapoc
- Packaging
- 100mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 29679
- Product name
- Senicapoc
- Packaging
- 1g
- Price
- $426
- Updated
- 2024/03/01
- Product number
- 29679
- Product name
- Senicapoc
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29679
- Product name
- Senicapoc
- Packaging
- 500mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- FS100781
- Product name
- Senicapoc
- Packaging
- 50mg
- Price
- $262.5
- Updated
- 2021/12/16
Senicapoc Chemical Properties,Usage,Production
Description
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.
Uses
Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.
Definition
Senicapoc (ICA-17043; bis(4-fluorophenyl)phenyl acetamide), a selective, highly potent Gardos channel blocker (IC50 = 11 nM), specifically inhibits the efflux of potassium from the RBCs of both SCD transgenic mice and human sickle cell disease patients. It is derived from clotrimazole-1, a KCNN4 inhibitor. Senicapoc is well tolerated by both healthy volunteers and patients with SCD and has favourable pharmacokinetics, with a long half-life permitting once-daily dosing. It was designed for long-term sickle cell disease therapy to avoid clotrimazole-1 side effects. Whereas Senicapoc is a potent inhibitor of WT KCNN4, its efficiency on mutated channels was unknown[1-2].
References
[1] Raphael Rapetti-Mauss. “Senicapoc: a potent candidate for the treatment of a subset of hereditary xerocytosis caused by mutations in the Gardos channel.” Haematologica 101 11 (2016): e431–e435.
[2] Kenneth I Ataga. “Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia.” Blood (2008): 3991–7.
Senicapoc Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Senicapoc manufacturers
- Product
- Senicapoc 289656-45-7
- Price
- US $0.00-0.00/MG
- Min. Order
- 10MG
- Purity
- 99.0%min. HPLC
- Supply Ability
- 10000
- Release date
- 2024-09-10
- Product
- Senicapoc 289656-45-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Senicapoc 289656-45-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09