ChemicalBook > CAS DataBase List > 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

Product Name
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
CAS No.
289656-45-7
Chemical Name
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
Synonyms
Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
CBNumber
CB31261049
Molecular Formula
C20H15F2NO
Formula Weight
323.34
MOL File
289656-45-7.mol
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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Property

Melting point:
180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
Boiling point:
460.7±45.0 °C(Predicted)
Density 
1.250±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
form 
Powder
pka
15.41±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29679
Product name
Senicapoc
Packaging
100mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
29679
Product name
Senicapoc
Packaging
1g
Price
$426
Updated
2024/03/01
Cayman Chemical
Product number
29679
Product name
Senicapoc
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29679
Product name
Senicapoc
Packaging
500mg
Price
$243
Updated
2024/03/01
Biosynth Carbosynth
Product number
FS100781
Product name
Senicapoc
Packaging
50mg
Price
$262.5
Updated
2021/12/16
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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Chemical Properties,Usage,Production

Description

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.

Uses

Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Suppliers

China 65 India 1 United Kingdom 1 United States 11 Global 78
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
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China
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1813
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Chembest Research Laboratories Limited
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021-20908456
Fax
021-58180499
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sales@BioChemBest.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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sales@capotchem.com
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China
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Shanghai Fuhe Chemistry Technology Co., Ltd.
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0086-21-67651709
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0086-21-67651705
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cfx759@hotmail.com
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China
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Shanghai T&W Pharmaceutical Co., Ltd.
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+86 21 61551611
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+86 21 50676805
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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18521735133 18521732826;
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021-50323701
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market@aladdin-e.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Shanghai Raise Chemical Technology Co.,Ltd
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+86-021-50935922
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+86-021-33847795
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China
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TargetMol Chemicals Inc.
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021-33632979 15002134094
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021-33632979
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marketing@targetmol.com
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China
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7934
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View Lastest Price from 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Senicapoc 289656-45-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Senicapoc 289656-45-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide 289656-45-7
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-16

289656-45-7, 2,2-bis(4-fluorophenyl)-2-phenyl-acetamideRelated Search:

2-FLUOROPHENYL CYCLOPENTYL KETONE 2,6-Difluorobenzamide 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

  • 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
  • Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-
  • 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
  • 4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide
  • ICA 17043
  • Senicapoc
  • ICA-17043;ICA 17043;ICA17043
  • Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
  • Senicapoc (ICA17043)
  • 289656-45-7
  • C20H15F2NO