2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

ChemicalBook > CAS DataBase List > 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

Product Name: 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
CAS No.: 289656-45-7
Chemical Name: 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
Synonyms: Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
CBNumber: CB31261049
Molecular Formula: C20H15F2NO
Formula Weight: 323.34
MOL File: 289656-45-7.mol

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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Property

Melting point:: 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
Boiling point:: 460.7±45.0 °C(Predicted)
Density: 1.250±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
form: Powder
pka: 15.41±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29679
Product name: Senicapoc
Packaging: 100mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 29679
Product name: Senicapoc
Packaging: 1g
Price: $426
Updated: 2024/03/01

Cayman Chemical

Product number: 29679
Product name: Senicapoc
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29679
Product name: Senicapoc
Packaging: 500mg
Price: $243
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FS100781
Product name: Senicapoc
Packaging: 50mg
Price: $262.5
Updated: 2021/12/16

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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Chemical Properties,Usage,Production

Description

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IK_Ca1/K_Ca3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC₅₀s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IK_Ca1/K_Ca3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3⁺ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.

Uses

Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Senicapoc 289656-45-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Senicapoc 289656-45-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide 289656-45-7
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-16

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