Imipenem-Cilastatin sodium hydrate

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Imipenem-Cilastatin sodium hydrate

Product Name: Imipenem-Cilastatin sodium hydrate
CAS No.: 92309-29-0
Chemical Name: Imipenem-Cilastatin sodium hydrate
Synonyms: Thienam;Primaxin;Tienam 500;Mk 787-mk 791 mixture;Mk 0787-mk 0791 mixture;85960-17-4 (Hydrochloride salt);Imipenem-Cilastatin sodium hydrate;Imipenem-Cilastatin sodium hydrate USP/EP/BP;IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate;TIANFU-CHEM CAS:92309-29-0 Imipenem-Cilastatin sodium hydrate
CBNumber: CB31261281
Molecular Formula: C28H43N5O9S2
Formula Weight: 657.8
MOL File: 92309-29-0.mol

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Hazard and Precautionary Statements (GHS)

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Imipenem-Cilastatin sodium hydrate Chemical Properties,Usage,Production

Clinical Use

Antibacterial agent

Drug interactions

Potentially hazardous interactions with other drugs
Antiepileptics: reduced valproate concentration - avoid.
Antivirals: convulsions reported with concomitant administration of ganciclovir and valganciclovir.
Ciclosporin: variable reports of increase / no change in ciclosporin levels, and of neurotoxicity.

Metabolism

When administered alone, imipenem is metabolised in the kidneys by dehydropeptidase-I, an enzyme in the brush border of the renal tubules, to inactive, nephrotoxic metabolites, with only about 5 to 40 or 45% of a dose excreted in the urine as unchanged active drug. Cilastin inhibits the metabolism of imipenem. When given with cilastatin about 70% of an intravenous dose of imipenem is recovered unchanged in the urine within 10 hours. Cilastatin is also excreted mainly in the urine, the majority as unchanged drug and about 12% as N-acetyl cilastatin. Less than 1% of imipenem is excreted via the bile in the faeces.

Imipenem-Cilastatin sodium hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Imipenem-Cilastatin sodium hydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Imipenem-Cilastatin sodium hydrate 92309-29-0
Price: US $0.00/KG/Tin
Min. Order: 5KG
Purity: Imipenem≥400μg/mg，Cilastatin(C16H26N2O5S) ≥400μg/mg;USP
Supply Ability: 100KGS
Release date: 2021-07-07

Career Henan Chemical Co

Product: Imipenem-Cilastatin sodium hydrate 92309-29-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

92309-29-0, Imipenem-Cilastatin sodium hydrateRelated Search:

Sodium hydroxide Imipenem Sodium acetate Cilastatin Cilastatin sodium CHLOROPHOSPHONAZO III Sodium formate (5R,6S)-3-[(Diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester Chloral hydrate Diclofenac sodium Sodium bicarbonate Imipenem Sodium gluconate Sodium benzoate Moxifloxacin hydrochloride hydrazine hydrate hydrate Imipenem-Cilastatin sodium hydrate

Primaxin

Thienam

Tienam 500

IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate

7-[(2S)-2-amino-2-carboxy-ethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopro panecarbonyl]amino]hept-2-enoic acid: (5R)-3-[2-(aminomethylideneamino )ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene -2-carboxylic acid

Imipenem-Cilastatin sodium hydrate

Sodium (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1R)-1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-(((2R)-2-amino-2-carboxyethyl)thio)-2-((((1S)-2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptenoic acid

1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R-(5alpha,6alpha(R*)))-, mixt. with (R-(R*,S*-(Z)))-7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptanoic acid

85960-17-4 (Hydrochloride salt)

Mk 0787-mk 0791 mixture

Mk 787-mk 791 mixture

Imipenem-Cilastatin sodium hydrate USP/EP/BP

TIANFU-CHEM CAS:92309-29-0 Imipenem-Cilastatin sodium hydrate

(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoicacid,(5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicaci

92309-29-0

C28H43N5O9S2

C12H17N3O4SC16H25N2NaO5SH2O