Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester

Product Name: Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester
CAS No.: 2411744-76-6
Chemical Name: Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester
Synonyms: α-Glucosidase-IN-11;Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester
CBNumber: CB312768706
Molecular Formula: C23H20N2O6
Formula Weight: 420.41
MOL File: 2411744-76-6.mol

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Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester Property

Boiling point:: 785.1±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
pka: 9.60±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester Chemical Properties,Usage,Production

Uses

α-Glucosidase-IN-11 is a highly permeable competitive α-glucosidase inhibitor with the IC50 value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels[1].

in vivo

α-Glucosidase-IN-11 (compound 3k) (gastric gavage, 60 mg/kg, everyday, 4 weeks) can improve blood glucose levels during fasting^[1].

Animal Model:	Male Sprague Dawley rats (250e320g)^[1]
Dosage:	60 mg/kg
Administration:	Gastric gavage; everyday; 4 weeks
Result:	Caused a significant drop in fasting blood glucose during the first and second weeks but did not cause a decrease in non-fasting blood glucose for up to four weeks.

References

[1] Tania Luthra, et al. Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes. Eur J Med Chem. 2020 Feb 15;188:112034. DOI:10.1016/j.ejmech.2020.112034

Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester Preparation Products And Raw materials

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Preparation Products

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Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester Suppliers

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2411744-76-6, Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl esterRelated Search:

α-Glucosidase-IN-29 KRN7000 α-galactosidase 5H-Indeno[1,2-b]pyridin-5-one, 6,7-dimethoxy-4-methyl- 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-(phenylthio)- Benzenesulfonamide, N-[4-[5-(4-chlorophenyl)-1-oxo-2,4-pentadien-1-yl]phenyl]-4-(trifluoromethyl)- ALPHA-GUANIDINOGLUTARIC ACID 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-bromo-3,5-dimethoxyphenyl)-6-(phenylthio)-

Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester

α-Glucosidase-IN-11

2411744-76-6