KRN7000

Product Name: KRN7000
CAS No.: 158021-47-7
Chemical Name: KRN7000
Synonyms: Α-GALACTOSYLCERAMIDE;S34;KRN7000;α-Galactosyl Ceramide;alpha-D-Galactosylceramide;alpha-Galactosylceramide, NKT cell stimulator;alpha-Galactosylceramide(a-Gal-Cer) (synthetic);α-Galactosyl Ceramide Supplier: Funakoshi Co. Ltd.;1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine;1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine
CBNumber: CB0501572
Molecular Formula: C50H99NO9
Formula Weight: 858.32
MOL File: 158021-47-7.mol

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KRN7000 Property

Melting point:: 125-130°C
Boiling point:: 939.8±65.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Pyridine (Slightly, Heated)
form: White solid.
pka: 12.92±0.70(Predicted)
color: White to Pale Beige
Stability:: Hygroscopic
CAS DataBase Reference: 158021-47-7

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Safety

WGK Germany: 3
HS Code: 2940.00.6000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 67576
Product name: (2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol
Purity: ≥95% (TLC)
Packaging: 1mg
Price: $960.5
Updated: 2025/07/31

TCI Chemical

Product number: G0509
Product name: α-Galactosylceramide
Purity: >95.0%(HPLC)
Packaging: 1mg
Price: $198
Updated: 2025/07/31

Cayman Chemical

Product number: 11208
Product name: KRN 7000
Purity: ≥96%
Packaging: 500 μg
Price: $197
Updated: 2024/03/01

Cayman Chemical

Product number: 11208
Product name: KRN 7000
Purity: ≥96%
Packaging: 1mg
Price: $253
Updated: 2024/03/01

Cayman Chemical

Product number: 11208
Product name: KRN 7000
Purity: ≥96%
Packaging: 250μg
Price: $115
Updated: 2022/04/27

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KRN7000 Chemical Properties,Usage,Production

Description

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Chemical Properties

White Solid

Uses

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Uses

Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.

Definition

ChEBI: A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.

storage

-20°C

References

[1] H. J. J. VAN DER VLIET. Effects of α-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Vα24+ Vβ11+ T cells[J]. Immunology, 2001, 98 4: 557-563. DOI: 10.1046/j.1365-2567.1999.00920.x
[2] NOEMI A. SAAVEDRA-AVILA, AMY R. HOWELL* A Humanized Mouse Model Coupled with Computational Analysis Identifies Potent Glycolipid Agonist of Invariant NKT Cells[J]. ACS Chemical Biology, 2024, 19 4: 926-937. DOI: 10.1021/acschembio.3c00736
[3] DEYING YANG . Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development[J]. Acta Pharmaceutica Sinica. B, 2022, 12 12: Pages 4432-4445. DOI: 10.1016/j.apsb.2022.05.028

KRN7000 Preparation Products And Raw materials

Raw materials

Preparation Products

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KRN7000 Suppliers

Americas 1 Canada 1 China 103 Europe 1 Germany 1 India 2 Japan 1 United Kingdom 1 United States 12 Global 123

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Yichang Zhongyitai Trading Co., Ltd.

Tel: 0717-6449896 13886658719
Fax: 0717-6558598
Email: root@zhongyitai.com
Country: China
ProdList: 1978
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

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View Lastest Price from KRN7000 manufacturers

Hangzhou MolCore BioPharmatech Co.,Ltd.

Product: KRN7000 158021-47-7
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: kgs
Release date: 2023-12-29

GlycoPharm.LLC

Product: (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Synonym:?α-GalCer or KRN7000 158021-47-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: 97%HPLC
Supply Ability: MG-KG
Release date: 2020-03-17

158021-47-7, KRN7000Related Search:

C16 CERAMIDE C18 CERAMIDE N-(2-hydroxypropyl)stearamide C14 Dihydroceramide DL-ERYTHRO-DIHYDROSPHINGOSINE C2 DIHYDROCERAMIDE Phytosphingosine C14 CERAMIDE KRN7000 C22 Dihydroceramide C22 Ceramide N-PALMITOYL SERINOL DL-1,3-DIHYDROXY-2-AMINO-OCTADECANE N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE N-(2R-HYDROXYPROPYL)-HEXADECANAMIDE C18 Dihydroceramide C4 Dihydroceramide N-LIGNOCEROYL-DL-DIHYDROSPHINGOSINE

(2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Synonym:α-GalCer or KRN7000

Α-GALACTOSYLCERAMIDE

KRN7000

N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide

1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine

(2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol

Hexacosanamide, N-[(1S,2S,3R)-1-[(α-D-galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]-

alpha-Galactosylceramide(a-Gal-Cer) (synthetic)

α-Galactosyl Ceramide

1-O-(α-D-galactosyl)-N-hexacosanoylphytosphingosine

S34

α-Galactosyl Ceramide Supplier: Funakoshi Co. Ltd.

alpha-D-Galactosylceramide

N-((2S,3S,4R)-3,4-Dihydroxy-1-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadecan-2-yl)hexacosanamide

alpha-Galactosylceramide, NKT cell stimulator

158021-47-7

C50H99NO9

Amino Acids & Derivatives

Protein Kinase Inhibitors and Activators

Amino Acids 13C, 2H, 15N