Tamsulosin
- Product Name
- Tamsulosin
- CAS No.
- 106133-20-4
- Chemical Name
- Tamsulosin
- Synonyms
- TAMSULOSINE;Tamsulosin Base;TAMSOLUSIN;Tamsulosin USP/EP/BP;Amsulosin;TAMSULOSIN;TANSULOSIN;TamsulosinRHCl;TaMsulosin USP;Tamsulosin 106133-20-4
- CBNumber
- CB3128875
- Molecular Formula
- C20H28N2O5S
- Formula Weight
- 408.51
- MOL File
- 106133-20-4.mol
Tamsulosin Property
- Melting point:
- 226-228°C
- Boiling point:
- 595.5±60.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO: 100 mg/mL (244.79 mM)
- form
- Solid
- pka
- 10.08±0.60(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 106133-20-4(CAS DataBase Reference)
Safety
- Hazardous Substances Data
- 106133-20-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-2896
- Product name
- Tamsulosin
- Purity
- 99.62%
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-2896
- Product name
- Tamsulosin
- Purity
- 99.62%
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-2896
- Product name
- Tamsulosin
- Purity
- 99.62%
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- API0010078
- Product name
- TAMSULOSIN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $374.85
- Updated
- 2021/12/16
- Product number
- 093796
- Product name
- (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)-propyl)-2-methoxybenzenesulfonamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $530
- Updated
- 2021/12/16
Tamsulosin Chemical Properties,Usage,Production
Description
Tamsulosin hydrochloride is the first in the class of potent and selective α- 1A adrenoceptor antagonists introduced for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). In a clinical study, significant improvement in irritative and obstructive symptoms has been reported for tamsulosin treated patients with BPH. ln vitro studies in human penile erectile tissue and vas deferens indicated that tamsulosin may be of use in treating male sexual dysfunction.
Originator
Yamanouchi (Japan)
Uses
tamsulosin
Uses
chemotherapy drug
Definition
ChEBI: Tamsulosin is a 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones. It has a role as an alpha-adrenergic antagonist and an antineoplastic agent. It is a conjugate base of a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin.
Manufacturing Process
In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2-
ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2-
methoxybenzenesulfonamide hydrochloride and while stirring the suspension,
9 g of thionyl chloride was added dropwise to the suspension at room
temperature, whereby the product first dissolved and then began to crystallize
gradually. After stirring the mixture for two days, the crystals formed were
recovered by filtration, washed with chloroform and dried to provide 15 g of
5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-
methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2-
ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide
hydrochloride and after adding thereto 10% palladium carbon, dechlorination
was performed under hydrogen stream at normal temperature and pressure.
The palladium carbon was filtered away and the filtrate was concentrated
under reduced pressure to provide the 2-methoxy-5-{2-[2-(2-
ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which
was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by
volume ratio) to provide the colorless crystals thereof. The melting point of
the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2-
methoxybenzenesulfonamide hydrochloride: 254°-256°C.
brand name
Harnal
Therapeutic Function
Antihypertensive
General Description
Tamsulosin (Flomax), a nonquinazoline benzensulfonamide,is the first in the class of subtype selective 1Ablocker.It is many folds more selective for α1A-receptorsthan for the other α1-receptors. This selectivity may favorblockade of α1A-receptors found in the prostate gland overthose found in vascular tissue. Tamsulosin is efficacious inthe treatment of BPH with little effect on blood pressure.Orthostatic hypotension is not as great with this agent aswith the nonselective quinazolines.
Tamsulosin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tamsulosin manufacturers
- Product
- Tamsulosin 106133-20-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%,USP
- Supply Ability
- 500kg/month
- Release date
- 2021-07-23
- Product
- Tamsulosin 106133-20-4
- Price
- US $50.00-30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20Tons
- Release date
- 2023-10-09
- Product
- Tamsulosin 106133-20-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 2000kg
- Release date
- 2023-06-09