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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-

Product Name
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
CAS No.
1026587-58-5
Chemical Name
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
Synonyms
Xanthine oxidoreductase-IN-4;N-(4-Ethoxyphenyl)-4-(1H-tetrazol-5-yl)benzamide;Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
CBNumber
CB312971894
Molecular Formula
C16H15N5O2
Formula Weight
309.32
MOL File
1026587-58-5.mol
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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Property

Density 
1.332±0.06 g/cm3(Predicted)
pka
3.81±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Chemical Properties,Usage,Production

Uses

Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia[1].

in vivo

Xanthine oxidoreductase-IN-4 (Compound IIIc) (oral; 5 mg/kg) shows a significant hypouricemia effect in a potassium oxazinate/hypoxanthine-induced model of acute hyperuricemia[1].

Animal Model:Mice acute hyperuricemia model[1]
Dosage:5 mg/kg
Administration:Oral
Result:Reduced serum levels of uric acid significantly from 4 h after administration.

References

[1] Wen Peng, et al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. DOI:10.1016/j.ejmech.2022.114947

Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Suppliers

China 13 United States 1 Global 14
Shanghai YuanYe Biotechnology Co., Ltd.
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1026587-58-5, Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-Related Search:

Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)- Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-

  • Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
  • Xanthine oxidoreductase-IN-4
  • N-(4-Ethoxyphenyl)-4-(1H-tetrazol-5-yl)benzamide
  • 1026587-58-5