Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-

Product Name: Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
CAS No.: 1026587-58-5
Chemical Name: Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
Synonyms: Xanthine oxidoreductase-IN-4;N-(4-Ethoxyphenyl)-4-(1H-tetrazol-5-yl)benzamide;Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
CBNumber: CB312971894
Molecular Formula: C16H15N5O2
Formula Weight: 309.32
MOL File: 1026587-58-5.mol

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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Property

Density: 1.332±0.06 g/cm3(Predicted)
pka: 3.81±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Chemical Properties,Usage,Production

Uses

Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia[1].

in vivo

Xanthine oxidoreductase-IN-4 (Compound IIIc) (oral; 5 mg/kg) shows a significant hypouricemia effect in a potassium oxazinate/hypoxanthine-induced model of acute hyperuricemia^[1].

Animal Model:	Mice acute hyperuricemia model^[1]
Dosage:	5 mg/kg
Administration:	Oral
Result:	Reduced serum levels of uric acid significantly from 4 h after administration.

References

[1] Wen Peng, et al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. DOI:10.1016/j.ejmech.2022.114947

Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Suppliers

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1026587-58-5, Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-Related Search:

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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-

Xanthine oxidoreductase-IN-4

N-(4-Ethoxyphenyl)-4-(1H-tetrazol-5-yl)benzamide

1026587-58-5