Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-

Product Name: Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-
CAS No.: 651769-78-7
Chemical Name: Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-
Synonyms: Xanthine oxidoreductase-IN-3;N-(4-Chlorophenyl)-4-(1H-tetrazol-5-yl)benzamide;Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-
CBNumber: CB53250881
Molecular Formula: C14H10ClN5O
Formula Weight: 299.7151
MOL File: 651769-78-7.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)- Chemical Properties,Usage,Production

Uses

Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].

in vivo

Xanthine oxidoreductase-IN-3 (compound IIIa) (5 mg/kg; p.o.) shows a uric acid-lowering effect from 3 h after administration in mice with acute hyperuricemia^[1].

Animal Model:	ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine^[1]
Dosage:	5 mg/kg
Administration:	Suspended in 0.5% CMC-Na solution for intragastric administration
Result:	Showed a uric acid-lowering effect from 3 h after administration.

References

[1] Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. DOI:10.1016/j.ejmech.2022.114947

Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)- Preparation Products And Raw materials

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Preparation Products

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651769-78-7, Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-Related Search:

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Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)-

Xanthine oxidoreductase-IN-3

N-(4-Chlorophenyl)-4-(1H-tetrazol-5-yl)benzamide

651769-78-7