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Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-

Product Name
Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
CAS No.
2642137-96-8
Chemical Name
Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
Synonyms
Xanthine oxidase-IN-4;Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
CBNumber
CB211410746
Molecular Formula
C15H13N5O2
Formula Weight
295.3
MOL File
2642137-96-8.mol
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Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Property

Boiling point:
404.2±45.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
pka
5.93±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Chemical Properties,Usage,Production

Uses

Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].

in vivo

Xanthine oxidase-IN-4 (compound 19a) (SD rats, 10 mg/kg, Intragastrically, once) significantly reduces the serum concentration of uric acid[1].

Animal Model:Sprague-Dawley rats (Six weeks, male, 180-200g, six groups)[1]
Dosage:10 mg/kg
Administration:Intragastrically, once
Result:Significantly reduced the serum concentration of uric acid, with AUC (uric acid, 1-5 h) of 44.3%.

References

[1] Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086. DOI:10.1016/j.ejmech.2021.114086

Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Suppliers

China 1 United States 1 Global 2
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TargetMol Chemicals Inc.
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+17819995354
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2642137-96-8, Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-Related Search:

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  • Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)-
  • Xanthine oxidase-IN-4
  • 2642137-96-8