Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-

Product Name: Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-
CAS No.: 2276711-87-4
Chemical Name: Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-
Synonyms: Xanthine oxidase-IN-5;Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-
CBNumber: CB012743870
Molecular Formula: C18H16FN3O3
Formula Weight: 341.34
MOL File: 2276711-87-4.mol

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Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Property

Boiling point:: 558.8±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
pka: 0.30±0.12(Predicted)

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Hazard and Precautionary Statements (GHS)

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Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Chemical Properties,Usage,Production

Uses

Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model[1].

in vivo

Xanthine oxidase-IN-5 (compound 9m) shows potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate^[1].

Animal Model:	Potassium oxonate-induced hyperuricemic rat model^[1]
Dosage:	20 mg/kg
Administration:	PO; single (measured serum uric acid after 0.5 - 8 hours)
Result:	Showed potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate.

References

[1] Zhang TJ, Zhang Y, Zhang ZH, et al. Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2022;60:128582. DOI:10.1016/j.bmcl.2022.128582

Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Preparation Products And Raw materials

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Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]- Suppliers

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TargetMol Chemicals Inc.

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2276711-87-4, Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-Related Search:

5-Amino-1-(4-trifluoromethylphenyl)-1H-pyrazole-4-carbonitrile Benzonitrile, 5-(2,3-dihydro-3-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-2-(1-methylethoxy)- Benzamide, N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)- XANTHOSINE DIHYDRATE 1H-Indole-3-carbonitrile, 1-cyclopentyl-5-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)- Xanthyletin Acetamide, N-(2-aminoethyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-, hydrochloride (1:1)

Benzaldehyde, 5-fluoro-2-[[1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy]-

Xanthine oxidase-IN-5

2276711-87-4