ChemicalBook > CAS DataBase List > Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)-
Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)-
- Product Name
- Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)-
- CAS No.
- 1026652-90-3
- Chemical Name
- Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)-
- Synonyms
- Xanthine oxidoreductase-IN-5;N-(4-Isopropoxyphenyl)-4-(1H-tetrazol-5-yl)benzamide;Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)-
- CBNumber
- CB512878944
- Molecular Formula
- C17H17N5O2
- Formula Weight
- 323.35
- MOL File
- 1026652-90-3.mol
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Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)- Property
- Density
- 1.298±0.06 g/cm3(Predicted)
- pka
- 3.82±0.10(Predicted)
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Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)- Chemical Properties,Usage,Production
Uses
Xanthine oxidoreductase-IN-5 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 55 nM. Xanthine oxidoreductase-IN-5 can be used for the research of acute hyperuricemia[1].
in vivo
Xanthine oxidoreductase-IN-5 (compound IIIe) (5 mg/kg; p.o.) shows a uric acid-lowering effect from 5 h after administration in mice with acute hyperuricemia[1].
| Animal Model: | ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] |
| Dosage: | 5 mg/kg |
| Administration: | Suspended in 0.5% CMC-Na solution for intragastric administration |
| Result: | Showed a uric acid-lowering effect from 5 h after administration. |
References
[1] Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. DOI:10.1016/j.ejmech.2022.114947
Benzamide, N-[4-(1-methylethoxy)phenyl]-4-(2H-tetrazol-5-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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