ChemicalBook > CAS DataBase List > Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)

Product Name
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
CAS No.
59215-36-0
Chemical Name
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
Synonyms
1-(4-Methyl-2-pyrimidinyl)piperazine;4-Methyl-2-(1-piperazinyl)pyrimidine;1-(4-methyl-pyrimidin-2-yl)piperazine;Pyrimidine,4-methyl-2-(1-piperazinyl);Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
CBNumber
CB31302986
Molecular Formula
C9H14N4
Formula Weight
178.23
MOL File
59215-36-0.mol
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Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Property

Melting point:
45-48℃
Boiling point:
170 °C(Press: 20 Torr)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
8.68±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
085667
Product name
4-Methyl-2-piperazin-1-ylpyrimidine
Purity
97%
Packaging
1g
Price
$360
Updated
2021/12/16
AK Scientific
Product number
W7211
Product name
4-Methyl-2-(1-piperazinyl)pyrimidine
Packaging
1g
Price
$536
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0069806
Product name
4-METHYL-2-PIPERAZIN-1-YLPYRIMIDINE
Purity
95.00%
Packaging
1G
Price
$795.56
Updated
2021/12/16
Chemenu
Product number
CM129197
Product name
4-methyl-2-(piperazin-1-yl)pyrimidine
Purity
95%
Packaging
1g
Price
$206
Updated
2021/12/16
Atlantic Research Chemicals
Product number
XS03818
Product name
4-Methyl-2-piperazin-1-ylpyrimidine
Purity
95%
Packaging
1gm:
Price
$236.82
Updated
2021/12/16
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Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Chemical Properties,Usage,Production

Synthesis

110-85-0

13036-57-2

59215-36-0

GENERAL METHOD: 2-Chloro-4,6-disubstituted pyrimidines were prepared by reacting the diazonium salt of 4,6-disubstituted pyrimidin-2-amines with concentrated hydrochloric acid and zinc chloride. In the reference, 23 compounds were synthesized by improving the method. The procedure was as follows: 2-chloro-4-methylpyrimidine (18 mmol) was added batchwise to a stirred solution of piperazine (45 mmol) and potassium carbonate (16.5 mmol) in water (20 mL) at 50-60 °C. The reaction mixture was stirred at 60-65 °C for 1 h and subsequently cooled to room temperature. The resulting yellow solid 1,4-bis(4,6-disubstituted pyrimidin-2-yl)piperazine was collected by filtration. The filtrate was extracted three times with chloroform, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-methyl-2-(1-piperazinyl)pyrimidine, which could be used in the subsequent reaction without further purification. Product 3a is a yellow solid with 81% yield and 45-48°C melting point; product 3b is a yellow solid with 79% yield and 82-84°C melting point.

References

[1] Chinese Journal of Chemistry, 2015, vol. 33, # 10, p. 1124 - 1134
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2016, vol. 191, # 1, p. 48 - 54
[3] Letters in Drug Design and Discovery, 2016, vol. 13, # 4, p. 343 - 351
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 167 - 178
[5] Journal of Fluorine Chemistry, 2016, vol. 184, p. 36 - 44

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Suppliers

China 30 Europe 1 United Kingdom 1 United States 4 Global 36
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View Lastest Price from Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) manufacturers

Career Henan Chemical Co
Product
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) 59215-36-0
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

59215-36-0, Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)Related Search:

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine MCI 225 2-[4-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]PIPERAZINO]ETHAN-1-OL 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE Pyrimidine, 5-methyl-2-(1-piperazinyl)- (9CI) Pyrimidine, 2-methyl-4-(1-piperazinyl)- (9CI) N-[(2,6-DICHLOROPYRIDIN-4-YL)CARBONYL]-N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE 2,3,3-TRICHLORO-1-(4-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]PIPERAZINO)PROP-2-EN-1-ONE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N'-(1-OXO-2,2-DIPHENYLETHYL)PIPERAZINE N-(4-TERT-BUTYLBENZOYL)-N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE 1-[4-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZIN-1-YL]-N-[(4-METHYLPHENYL)SULPHONYL]FORMAMIDE N,N'-BIS(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N'-[3-(TRIFLUOROMETHYL)BENZOYL]PIPERAZINE N-(2,6-DIFLUOROBENZOYL)-N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE N-(2,4-DIFLUOROPHENYL)-1-[4-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZIN-1-YL]FORMAMIDE ASISCHEM C39807 [4-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZIN-1-YL]-N-ETHYLFORMAMIDE

  • Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
  • 4-Methyl-2-(1-piperazinyl)pyrimidine
  • 1-(4-Methyl-2-pyrimidinyl)piperazine
  • Pyrimidine,4-methyl-2-(1-piperazinyl)
  • 1-(4-methyl-pyrimidin-2-yl)piperazine
  • 59215-36-0
  • pyrimidine
  • Heterocycle-Pyrimidine series
  • PIPERIDINE
  • pharmacetical
  • Pyrans, Piperidines &Piperazines
  • Pyrans, Piperidines & Piperazines