ChemicalBook > CAS DataBase List > Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)

Product Name
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
CAS No.
59215-36-0
Chemical Name
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
Synonyms
1-(4-Methyl-2-pyrimidinyl)piperazine;4-Methyl-2-(1-piperazinyl)pyrimidine;1-(4-methyl-pyrimidin-2-yl)piperazine;Pyrimidine,4-methyl-2-(1-piperazinyl);Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
CBNumber
CB31302986
Molecular Formula
C9H14N4
Formula Weight
178.23
MOL File
59215-36-0.mol
More
Less

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Property

Melting point:
45-48℃
Boiling point:
170 °C(Press: 20 Torr)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
8.68±0.10(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Matrix Scientific
Product number
085667
Product name
4-Methyl-2-piperazin-1-ylpyrimidine
Purity
97%
Packaging
1g
Price
$360
Updated
2021/12/16
AK Scientific
Product number
W7211
Product name
4-Methyl-2-(1-piperazinyl)pyrimidine
Packaging
1g
Price
$536
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0069806
Product name
4-METHYL-2-PIPERAZIN-1-YLPYRIMIDINE
Purity
95.00%
Packaging
1G
Price
$795.56
Updated
2021/12/16
Chemenu
Product number
CM129197
Product name
4-methyl-2-(piperazin-1-yl)pyrimidine
Purity
95%
Packaging
1g
Price
$206
Updated
2021/12/16
Atlantic Research Chemicals
Product number
XS03818
Product name
4-Methyl-2-piperazin-1-ylpyrimidine
Purity
95%
Packaging
1gm:
Price
$236.82
Updated
2021/12/16
More
Less

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Chemical Properties,Usage,Production

Synthesis

110-85-0

13036-57-2

59215-36-0

GENERAL METHOD: 2-Chloro-4,6-disubstituted pyrimidines were prepared by reacting the diazonium salt of 4,6-disubstituted pyrimidin-2-amines with concentrated hydrochloric acid and zinc chloride. In the reference, 23 compounds were synthesized by improving the method. The procedure was as follows: 2-chloro-4-methylpyrimidine (18 mmol) was added batchwise to a stirred solution of piperazine (45 mmol) and potassium carbonate (16.5 mmol) in water (20 mL) at 50-60 °C. The reaction mixture was stirred at 60-65 °C for 1 h and subsequently cooled to room temperature. The resulting yellow solid 1,4-bis(4,6-disubstituted pyrimidin-2-yl)piperazine was collected by filtration. The filtrate was extracted three times with chloroform, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-methyl-2-(1-piperazinyl)pyrimidine, which could be used in the subsequent reaction without further purification. Product 3a is a yellow solid with 81% yield and 45-48°C melting point; product 3b is a yellow solid with 79% yield and 82-84°C melting point.

References

[1] Chinese Journal of Chemistry, 2015, vol. 33, # 10, p. 1124 - 1134
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2016, vol. 191, # 1, p. 48 - 54
[3] Letters in Drug Design and Discovery, 2016, vol. 13, # 4, p. 343 - 351
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 167 - 178
[5] Journal of Fluorine Chemistry, 2016, vol. 184, p. 36 - 44

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Suppliers

China 30 Europe 1 United Kingdom 1 United States 4 Global 36
Carbott PharmTech Inc.
Tel
0535-6385396
Fax
+86 (535) 638-9971
Email
info@carbottpharm.com
Country
China
ProdList
957
Advantage
56
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Adobe Chem Co., Ltd.
Tel
2332782371
Fax
QQ: 2332782371
Email
adobechem@qq.com
Country
China
ProdList
7980
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
(5)02557626880
Email
dt3@aikonchem.com
Country
China
ProdList
15493
Advantage
58
Yujinpharma(Tianjin) Technology Co.,Ltd.
Tel
13370351217 kungfu1217@1
Fax
QQ1400885609
Email
kungfu1217@163.com
Country
China
ProdList
2720
Advantage
58
Shanghai SPAR pharmaceutical technology co., LTD
Tel
021-000000 13917643586;
Email
admin@jingshipharmatech.com
Country
China
ProdList
9853
Advantage
58
Nantong Kaisheng Biotechnology Co., Ltd.
Tel
13951303301
Email
2084934672@qq.com
Country
China
ProdList
637
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Hebei Beckman Biotechnology Co., Ltd.
Tel
15961617865 15961617865;
Email
2245485247@qq.com
Country
China
ProdList
4599
Advantage
58
Zhengzhou Edward Biology Co.,Ltd
Tel
0371-63682289 15538176268
Fax
QQ：1875164801
Email
jacschem@163.com
Country
China
ProdList
9926
Advantage
58
Wuhan chuang he chemical co. LTD
Tel
15907120073
Fax
15527109962
Email
1261789306@qq.com
Country
China
ProdList
1312
Advantage
58
Haiji Pharmaceutical Technology (Suzhou) Co., Ltd
Tel
18012778619
Email
3394205705@qq.com
Country
China
ProdList
9841
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Birdo (Shanghai) Medical Technology Co., Ltd.
Tel
021-58099077-8041 18601625411
Email
sales@birdotech.com
Country
China
ProdList
9764
Advantage
58
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Ningbo jinuo chemical co., LTD
Tel
0574-87314919 057487319282
Email
info@nbinno.com
Country
China
ProdList
7047
Advantage
58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd
Tel
2383948258 19172820304
Email
2383948258@qq.com
Country
China
ProdList
12987
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Jiaxing Deyi Chemical Co., Ltd
Tel
0573-85866609 13588473046
Email
824930988@qq.com
Country
China
ProdList
7865
Advantage
58
Shanghai Haohong Scientific Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
029-81136151 17392212881
Email
1095@dideu.com
Country
China
ProdList
10001
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Jilin Chinese Academy of Sciences-yanshen Technology
Tel
+undefined18143011203
Email
info@chemextension.com
Country
China
ProdList
42056
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Atomax Chemicals Co., Ltd
Tel
--
Fax
--
Email
info@atomaxchem.com
Country
China
ProdList
6489
Advantage
43
More
Less

View Lastest Price from Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) manufacturers

Career Henan Chemical Co
Product
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) 59215-36-0
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

59215-36-0, Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)Related Search:

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine MCI 225 2-[4-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]PIPERAZINO]ETHAN-1-OL 1-(4,6-DIMETHYL-2-PYRIMIDYL)PIPERAZINE Pyrimidine, 5-methyl-2-(1-piperazinyl)- (9CI) Pyrimidine, 2-methyl-4-(1-piperazinyl)- (9CI) N-[(2,6-DICHLOROPYRIDIN-4-YL)CARBONYL]-N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE 2,3,3-TRICHLORO-1-(4-[4-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]PIPERAZINO)PROP-2-EN-1-ONE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N'-(1-OXO-2,2-DIPHENYLETHYL)PIPERAZINE N-(4-TERT-BUTYLBENZOYL)-N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE 1-[4-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZIN-1-YL]-N-[(4-METHYLPHENYL)SULPHONYL]FORMAMIDE N,N'-BIS(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE N-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N'-[3-(TRIFLUOROMETHYL)BENZOYL]PIPERAZINE N-(2,6-DIFLUOROBENZOYL)-N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZINE N-(2,4-DIFLUOROPHENYL)-1-[4-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZIN-1-YL]FORMAMIDE ASISCHEM C39807 [4-(4,6-DIMETHYLPYRIMIDIN-2-YL)PIPERAZIN-1-YL]-N-ETHYLFORMAMIDE

  • Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
  • 4-Methyl-2-(1-piperazinyl)pyrimidine
  • 1-(4-Methyl-2-pyrimidinyl)piperazine
  • Pyrimidine,4-methyl-2-(1-piperazinyl)
  • 1-(4-methyl-pyrimidin-2-yl)piperazine
  • 59215-36-0
  • pyrimidine
  • Heterocycle-Pyrimidine series
  • PIPERIDINE
  • pharmacetical
  • Pyrans, Piperidines &Piperazines
  • Pyrans, Piperidines & Piperazines