osthenol
- Product Name
- osthenol
- CAS No.
- 484-14-0
- Chemical Name
- osthenol
- Synonyms
- NSC 625328;Osthenol, 10 mM in DMSO;7-Hydroxy-8-prenylcoumarin;7-Hydroxy-8-isopentenyl-2H-1-benzopyran-2-one;7-Hydroxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one;7-Hydroxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 7-hydroxy-8-(3-methyl-2-buten-1-yl)-;inhibit,selective,Monoamine Oxidase,MAO,depression,competitive,Osthenol,Inhibitor,coumarin,Ostenol
- CBNumber
- CB31312338
- Molecular Formula
- C14H14O3
- Formula Weight
- 230.26
- MOL File
- 484-14-0.mol
osthenol Property
- Melting point:
- 89-91 °C
- Boiling point:
- 422.8±45.0 °C(Predicted)
- Density
- 1.203±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 8.45±0.20(Predicted)
- color
- White to yellow
- InChI
- InChI=1S/C14H14O3/c1-9(2)3-6-11-12(15)7-4-10-5-8-13(16)17-14(10)11/h3-5,7-8,15H,6H2,1-2H3
- InChIKey
- RAKJVIPCCGXHHS-UHFFFAOYSA-N
- SMILES
- C1(=O)OC2=C(C/C=C(/C)\C)C(O)=CC=C2C=C1
- LogP
- 3.342 (est)
N-Bromosuccinimide Price
- Product number
- CS-0022826
- Product name
- Osthenol
- Purity
- 98.91%
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- INB0001863
- Product name
- OSTHENOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499
- Updated
- 2021/12/16
- Product number
- SY232770
- Product name
- Damascenone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $190.91
- Updated
- 2021/12/16
osthenol Chemical Properties,Usage,Production
Chemical Properties
Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rhizoma et Radix Notopterygii.
Uses
Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 μM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 μM and shows a high selectivity index for hMAO-A versus hMAO-B[1].
Definition
ChEBI: Osthenol is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group. It has a role as a plant metabolite and an antifungal agent. It is functionally related to an umbelliferone.
Biological Activity
Ostenol (Ostenol), a preacylated coumarin isolated from the dried roots of Ostonia, is a reversible, selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) (Ki=0.26 μM) . Oshenol has a potential selective inhibitory effect on recombinant hMAO-A with IC50 of 0.74 μM, showing a high selectivity index for hMAO-A and hMAO-B.
IC 50
hMAO-A: 0.26 μM (Ki); hMAO-A: 0.74 μM (IC50)
References
[1] Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. DOI:10.1016/j.bmcl.2019.01.016
[2] Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003. DOI:10.19540/j.cnki.cjcmm.20170512.003
osthenol Preparation Products And Raw materials
Raw materials
Preparation Products
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