ChemicalBook > CAS DataBase List > 2-Hydroxy-4-quinolincarboxylic acid

2-Hydroxy-4-quinolincarboxylic acid

Product Name
2-Hydroxy-4-quinolincarboxylic acid
CAS No.
15733-89-8
Chemical Name
2-Hydroxy-4-quinolincarboxylic acid
Synonyms
AKOS AUF0188;RARECHEM AQ NN 0221;IFLAB-BB F1918-0080;2-hydroxycinchoninic;4-carboxycarbostyril;Cinchocaine impurity B;Piraxostat Impurity 7;2-hydroxy-cinchoninicaci;2-HYDROXYCINCHONINIC ACID;Cinchocaine EP Impurity B
CBNumber
CB3132467
Molecular Formula
C10H7NO3
Formula Weight
189.17
MOL File
15733-89-8.mol
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2-Hydroxy-4-quinolincarboxylic acid Property

Melting point:
350°C
Boiling point:
403.6±45.0 °C(Predicted)
Density 
1.429±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
2.76±0.20(Predicted)
color 
Yellow to Dark Yellow
BRN 
148331
InChI
InChI=1S/C10H7NO3/c12-9-5-7(10(13)14)6-3-1-2-4-8(6)11-9/h1-5H,(H,11,12)(H,13,14)
InChIKey
MFSHNFBQNVGXJX-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)C(C(O)=O)=CC1=O
LogP
0.3 at 25℃ and pH7
CAS DataBase Reference
15733-89-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
RTECS 
GD3869000
HazardClass 
IRRITANT
HS Code 
29337900
Toxicity
mouse,LD,intraperitoneal,> 500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 338, 1953.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS019980
Product name
2-Oxo-1,2-dihydroquinoline-4-carboxylic acid
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$73.1
Updated
2025/07/31
TCI Chemical
Product number
H1016
Product name
2-Hydroxyquinoline-4-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
H1016
Product name
2-Hydroxyquinoline-4-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$123
Updated
2025/07/31
TRC
Product number
D450530
Product name
1,​2-​Dihydro-​2-​oxo-4-​quinolinecarboxylicAcid
Packaging
100g
Price
$180
Updated
2021/12/16
Apolloscientific
Product number
OR911510
Product name
2-Hydroxyquinoline-4-carboxylic acid
Purity
98%
Packaging
100g
Price
$135
Updated
2021/12/16
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2-Hydroxy-4-quinolincarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

1,?2-?Dihydro-?2-?oxo-4-?quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.

Definition

ChEBI: 2-oxo-1,2-dihydroquinoline-4-carboxylic acid is a quinolinemonocarboxylic acid. It is a conjugate acid of a 2-oxo-1,2-dihydroquinoline-4-carboxylate.

Synthesis

141-82-2

91-56-5

15733-89-8

1. Add 400kg of recovered glacial acetic acid to the 1000L reactor and start stirring. 2. 100kg of indigo, 160kg of malonic acid and 15kg of sodium acetate were added sequentially to the reactor to ensure adequate mixing. 3. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. 4. Upon completion of the reaction, the acetic acid was removed by distillation under reduced pressure. 5. 300 kg of deionized water was added to the reaction mixture and stirred to promote crystal formation. 6. 6. The solid product was collected by filtration, washed with 30 kg of cold glacial acetic acid, and then rinsed with 30 kg of cold methanol to obtain the wet product of 2-quinolinone-4-carboxylic acid. 7. The wet product was dried at 45-70 °C for 24 h. 125 kg of 2-quinolinone-4-carboxylic acid was finally obtained with a yield of 97.3% and a liquid phase purity of 99.6%.

References

[1] Patent: CN108101842, 2018, A. Location in patent: Paragraph 0021; 0023
[2] Synthetic Communications, 2005, vol. 35, # 17, p. 2243 - 2250
[3] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 44
[4] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0271-0274
[5] Chemische Berichte, 1914, vol. 47, p. 358

2-Hydroxy-4-quinolincarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Hydroxy-4-quinolincarboxylic acid manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
2-Hydroxy-4-quinolincarboxylic acid 15733-89-8
Price
US $88.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000T
Release date
2023-07-24
Baoji Guokang Healthchem co.,ltd
Product
2-Hydroxy-4-quinolincarboxylic acid 15733-89-8
Price
US $278.00/ASSAYS
Min. Order
1KG
Purity
99
Supply Ability
1000kg
Release date
2021-06-04
Hebei Zhanyao Biotechnology Co. Ltd
Product
2-Hydroxy-4-quinolincarboxylic acid 15733-89-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-13

15733-89-8, 2-Hydroxy-4-quinolincarboxylic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Quinhydrone Folic acid 4,6-Dihydroxypyrimidine 4-Ethyl-5-fluoro-6-hydroxypyrimidine 2-Quinolinol Isoquinoline CHLOROPHOSPHONAZO III Chromium picolinate 8-Hydroxyquinoline Quinclorac Cinchocaine 2-Chloro-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide N-(2-(diethylamino)ethyl)-2-hydroxyquinoline-4-carboxamide Dibucaine IMpurity D Citric acid Ascoric Acid Carboxy styrene-butadiene latex

  • IFLAB-BB F1918-0080
  • AKOS AUF0188
  • 1,2-DIHYDRO-2-OXOQUINOLINE-4-CARBOXYLIC ACID
  • 2-HYDROXY-4-QUINOLINCARBOXYLIC ACID
  • 2-HYDROXYCINCHONINIC ACID
  • RARECHEM AQ NN 0221
  • 1,2-dihydro-2-oxo-4-quinolinecarboxylicaci
  • 2-hydroxy-cinchoninicaci
  • 4-carboxycarbostyril
  • 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID 98%
  • 2-hydroxycinchoninic
  • 2-Hydroxyquinoline-4-carboxylic acid hydrate, 98+%
  • 2-Hydroxy-4-quinolinecarboxylic acid
  • 2-Oxo-1,2-dihydroquinoline-4-carboxylic acid
  • ##USE H29247## 2-Hydroxyquinoline-4-carboxylic acid hydrate, 98+%
  • 4-quinolinecarboxylic acid, 2-hydroxy-
  • 2-Hydroxyquinoline-4-carboxylic acid, 98+%
  • 2-oxo-1,2-dihydroquinoline-4-carboxylic acid(SALTDATA: 0.7H2O)
  • 2-oxo-1,2-dihydroquinoline-4-carboxylic acid 0.7H2O
  • 2-Hydroxyquinolin-4-carboxylic acid
  • 1,2-Dihydro-2-oxoquinoline-4-carboxylic Acid 2-Hydroxycinchoninic Acid
  • 2-oxo-4-quinolinecarboxylic acid
  • 1,2-Dihydro-2-oxo-quinolin-4-carboxylic acid
  • Methyl 2-hydroxyquinoline-4-carboxylate
  • 1,2-Dihydro-2-oxo-4-quinolinecarboxylic acid
  • 4-Quinolinecarboxylicacid, 1,2-dihydro-2-oxo-
  • Cinchocaine EP Impurity B
  • 1,2-Dihydro-2-oxo-4-Cinchocaine EP Impurity B
  • Cinchocaine impurity B
  • 2-Hydroxyquinoline-4-carboxylicAcid&gt
  • Cinchocaine EP Impurity B (2-Hydroxyquinoline-4-Carboxylic Acid)
  • 1,2-Dihydro-2-Oxoquinoline-4-CarboxylicAci
  • 2-Hydroxy-4-quinolincarboxylic acid ISO 9001：2015 REACH
  • Cinchocaine Hydrochloride Impurity B
  • Cinchocaine Hydrochloride EP Impurity B
  • Piraxostat Impurity 7
  • Cinchocaine impurity B【Y0002032】
  • Cinchocaine Hydrochloride Imp. B (EP): 2-Hydroxyquinoline-4-
  • 15733-89-8
  • Hydroxyquinolines
  • Quinolines
  • Building Blocks
  • Heterocyclic Building Blocks
  • Hydroxyquinolines
  • Quinolines
  • Intermediate