2-Hydroxy-4-quinolincarboxylic acid
- Product Name
- 2-Hydroxy-4-quinolincarboxylic acid
- CAS No.
- 15733-89-8
- Chemical Name
- 2-Hydroxy-4-quinolincarboxylic acid
- Synonyms
- AKOS AUF0188;RARECHEM AQ NN 0221;IFLAB-BB F1918-0080;2-hydroxycinchoninic;4-carboxycarbostyril;Cinchocaine impurity B;Piraxostat Impurity 7;2-hydroxy-cinchoninicaci;2-HYDROXYCINCHONINIC ACID;Cinchocaine EP Impurity B
- CBNumber
- CB3132467
- Molecular Formula
- C10H7NO3
- Formula Weight
- 189.17
- MOL File
- 15733-89-8.mol
2-Hydroxy-4-quinolincarboxylic acid Property
- Melting point:
- 350°C
- Boiling point:
- 403.6±45.0 °C(Predicted)
- Density
- 1.429±0.06 g/cm3(Predicted)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 2.76±0.20(Predicted)
- color
- Yellow to Dark Yellow
- BRN
- 148331
- InChI
- InChI=1S/C10H7NO3/c12-9-5-7(10(13)14)6-3-1-2-4-8(6)11-9/h1-5H,(H,11,12)(H,13,14)
- InChIKey
- MFSHNFBQNVGXJX-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(C(O)=O)=CC1=O
- LogP
- 0.3 at 25℃ and pH7
- CAS DataBase Reference
- 15733-89-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36
- RTECS
- GD3869000
- HazardClass
- IRRITANT
- HS Code
- 29337900
- Toxicity
- mouse,LD,intraperitoneal,> 500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 338, 1953.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS019980
- Product name
- 2-Oxo-1,2-dihydroquinoline-4-carboxylic acid
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 100 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- H1016
- Product name
- 2-Hydroxyquinoline-4-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- H1016
- Product name
- 2-Hydroxyquinoline-4-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $123
- Updated
- 2025/07/31
- Product number
- D450530
- Product name
- 1,2-Dihydro-2-oxo-4-quinolinecarboxylicAcid
- Packaging
- 100g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- OR911510
- Product name
- 2-Hydroxyquinoline-4-carboxylic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $135
- Updated
- 2021/12/16
2-Hydroxy-4-quinolincarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
1,?2-?Dihydro-?2-?oxo-4-?quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.
Definition
ChEBI: 2-oxo-1,2-dihydroquinoline-4-carboxylic acid is a quinolinemonocarboxylic acid. It is a conjugate acid of a 2-oxo-1,2-dihydroquinoline-4-carboxylate.
Synthesis
141-82-2
91-56-5
15733-89-8
1. Add 400kg of recovered glacial acetic acid to the 1000L reactor and start stirring. 2. 100kg of indigo, 160kg of malonic acid and 15kg of sodium acetate were added sequentially to the reactor to ensure adequate mixing. 3. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. 4. Upon completion of the reaction, the acetic acid was removed by distillation under reduced pressure. 5. 300 kg of deionized water was added to the reaction mixture and stirred to promote crystal formation. 6. 6. The solid product was collected by filtration, washed with 30 kg of cold glacial acetic acid, and then rinsed with 30 kg of cold methanol to obtain the wet product of 2-quinolinone-4-carboxylic acid. 7. The wet product was dried at 45-70 °C for 24 h. 125 kg of 2-quinolinone-4-carboxylic acid was finally obtained with a yield of 97.3% and a liquid phase purity of 99.6%.
References
[1] Patent: CN108101842, 2018, A. Location in patent: Paragraph 0021; 0023
[2] Synthetic Communications, 2005, vol. 35, # 17, p. 2243 - 2250
[3] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 44
[4] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0271-0274
[5] Chemische Berichte, 1914, vol. 47, p. 358
2-Hydroxy-4-quinolincarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxy-4-quinolincarboxylic acid Suppliers
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- 320-37350700
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View Lastest Price from 2-Hydroxy-4-quinolincarboxylic acid manufacturers
- Product
- 2-Hydroxy-4-quinolincarboxylic acid 15733-89-8
- Price
- US $88.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000T
- Release date
- 2023-07-24
- Product
- 2-Hydroxy-4-quinolincarboxylic acid 15733-89-8
- Price
- US $278.00/ASSAYS
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 1000kg
- Release date
- 2021-06-04
- Product
- 2-Hydroxy-4-quinolincarboxylic acid 15733-89-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-13