MKT 077
- Product Name
- MKT 077
- CAS No.
- 147366-41-4
- Chemical Name
- MKT 077
- Synonyms
- FJ 776;MKT 077;MKT-077, ≥98% (HPLC);MKT077;MKT-077;FJ-776;MKT-077, 10 mM in DMSO;MKT-077 >=98% (HPLC), powder;MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
- CBNumber
- CB31356358
- Molecular Formula
- C21H22ClN3OS2
- Formula Weight
- 432.00188
- MOL File
- 147366-41-4.mol
MKT 077 Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble10mg/mL, clear
- form
- powder
- color
- orange to red
- Water Solubility
- H2O: 10mg/mL, clear
Safety
- WGK Germany
- 3
- RTECS
- UU4023332
- Toxicity
- LD50 intraperitoneal in mouse: 50mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M5449
- Product name
- MKT-077
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $190
- Updated
- 2025/07/31
- Product number
- M5449
- Product name
- MKT-077
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $398
- Updated
- 2025/07/31
- Product number
- 14395
- Product name
- MKT-077
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 14395
- Product name
- MKT-077
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 14395
- Product name
- MKT-077
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $162
- Updated
- 2024/03/01
MKT 077 Chemical Properties,Usage,Production
Description
MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.
Uses
MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance
Biochem/physiol Actions
MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.
in vivo
Systemic administration of MKT-077 significantly delays the growth of TT xenografts in mice throughout the treatment. At the end of MKT-077 treatment, it is found that tumor weights are about two-times less in MKT-077-treated group than in control group. MKT-077 treatment also results in weight loss and general toxicity in animals[1]. Results show that the succinate-induced, ADP-stimulated respiratory rate in mitochondria isolated from the liver of rats treated with a bolus i.v. injection of 15 mg MKT-077 1kg body weight each day for 5 days is significantly lower than that of untreated controls[3].
IC 50
HSP70
storage
Store at +4°C
References
[1] XIAOKAI LI. Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents[J]. ACS Medicinal Chemistry Letters, 2013, 4 11: 1042-1047. DOI: 10.1021/ml400204n
[2] AIKATERINI ROUSAKI . Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones[J]. Journal of Molecular Biology, 2011, 411 3: Pages 614-632. DOI: 10.1016/j.jmb.2011.06.003
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
MKT 077 Preparation Products And Raw materials
Raw materials
Preparation Products
MKT 077 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from MKT 077 manufacturers
- Product
- MKT 077 147366-41-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26