MKT 077

Product Name: MKT 077
CAS No.: 147366-41-4
Chemical Name: MKT 077
Synonyms: FJ 776;MKT 077;MKT-077, ≥98% (HPLC);MKT077;MKT-077;FJ-776;MKT-077, 10 mM in DMSO;MKT-077 >=98% (HPLC), powder;MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
CBNumber: CB31356358
Molecular Formula: C21H22ClN3OS2
Formula Weight: 432.00188
MOL File: 147366-41-4.mol

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MKT 077 Property

storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: orange to red
Water Solubility: H2O: 10mg/mL, clear

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Safety

WGK Germany: 3
RTECS: UU4023332
Toxicity: LD50 intraperitoneal in mouse: 50mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5449
Product name: MKT-077
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5449
Product name: MKT-077
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $309.6
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 14395
Product name: MKT-077
Purity: ≥95%
Packaging: 10mg
Price: $162
Updated: 2024/03/01

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MKT 077 Chemical Properties,Usage,Production

Description

MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC₅₀s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.

Uses

MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance

Biochem/physiol Actions

MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.

storage

Store at +4°C

MKT 077 Preparation Products And Raw materials

Raw materials

Preparation Products

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MKT 077 Suppliers

China 63 India 3 United Kingdom 1 United States 10 Global 77

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

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Country: United States
ProdList: 6773
Advantage: 87

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View Lastest Price from MKT 077 manufacturers

Career Henan Chemical Co

Product: MKT 077 147366-41-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

147366-41-4, MKT 077Related Search:

MKT 077

FJ 776

1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride

MKT077;MKT-077;FJ-776

Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)

MKT-077 >=98% (HPLC), powder

1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride

MKT-077, ≥98% (HPLC)

MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776

MKT-077, 10 mM in DMSO

147366-41-4

C21H22ClN3OS2