2-HYDROXYETHYL PHOSPHONIC ACID
- Product Name
- 2-HYDROXYETHYL PHOSPHONIC ACID
- CAS No.
- 22987-21-9
- Chemical Name
- 2-HYDROXYETHYL PHOSPHONIC ACID
- Synonyms
- BRN 1751212;Einecs 245-370-6;(2-hydroxyethyl)-phosphonicaci;2-HYDROXYETHYL PHOSPHONIC ACID;2-Hydroxyethanephosphonic acid;P-(2-Hydroxyethyl)-phosphonic Acid;Phosphonic acid, (2-hydroxyethyl)-;Phosphonic acid, P-(2-hydroxyethyl)-;2-Hydroxyethyl phosphonic acid, 97 %;Ethephon-hydroxy 100 μg/mL in Acetonitrile
- CBNumber
- CB3137295
- Molecular Formula
- C2H7O4P
- Formula Weight
- 126.05
- MOL File
- 22987-21-9.mol
2-HYDROXYETHYL PHOSPHONIC ACID Property
- Boiling point:
- 398.8±44.0 °C(Predicted)
- Density
- 1.611±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Colourless to Red Thick Oil to Semi-Solid
- pka
- 2.25±0.10(Predicted)
- Appearance
- Colorless to light yellow Viscous Liquid
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C2H7O4P/c3-1-2-7(4,5)6/h3H,1-2H2,(H2,4,5,6)
- InChIKey
- SEHJHHHUIGULEI-UHFFFAOYSA-N
- SMILES
- P(CCO)(=O)(O)O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H939650
- Product name
- 2-HydroxyethanephosphonicAcid
- Packaging
- 25mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- ING0005866
- Product name
- 2-HYDROXYETHYL PHOSPHONIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.16
- Updated
- 2021/12/16
- Product number
- 40896
- Product name
- 2-HydroxyethanephosphonicAcid
- Packaging
- 250mg
- Price
- $2200
- Updated
- 2021/12/16
2-HYDROXYETHYL PHOSPHONIC ACID Chemical Properties,Usage,Production
Uses
2-Hydroxyethanephosphonic acid is an substrate used in the study of 2-hydroxyethylphosphonate dioxygenase reaction mechanism. 2-Hydroxyethanephosphonic Acid is also a required intermediate in labelled Fosfomycin (F727502) biosynthesis.
Definition
ChEBI: A phosphonic acid consisting of ethanol with the phospho group at the 2-position.
Synthesis
39118-50-8
22987-21-9
The general procedure for the synthesis of (2-hydroxyethyl)phosphonic acid from ethyl 2-(dimethoxyphosphono)acetate was as follows: to a 500 mL four-necked round-bottomed flask equipped with a heating jacket, thermocouples, a 10-pallet old Shore column and distillation head, were added sequentially dimethyl-2-(acetoxy)ethyl phosphonate (293 g, 1.5 mol), AMBERLYST-15 ion exchange resin (48 g) and water (72 g, 4 mol). The reaction mixture was heated to 100 °C. After 15 hours of reaction, the reaction temperature was raised to 105°C. During this process, the vapor temperature frequently reached 95 °C and the distillate was mainly water. Subsequently, about 150 g of additional water was added to the reaction system and the volatile components were removed under vacuum, resulting in 168 g (89% yield) of hydroxyethylphosphonic acid. The method avoids the use of stoichiometric HCl, thereby reducing the generation of corrosive and carcinogenic by-products (e.g., hydrochloric acid and methyl chloride), which are mainly methanol and methyl acetate, as compared to conventional methods. In addition, the method offers the advantage of easy recovery and reuse of the ion exchange resin.
References
[1] Patent: US2015/361117, 2015, A1. Location in patent: Paragraph 0009
[2] Phosphorus and Sulfur and the Related Elements, 1982, vol. 13, p. 363 - 370
2-HYDROXYETHYL PHOSPHONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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