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ALPHA-AMANITIN

Product Name
ALPHA-AMANITIN
CAS No.
23109-05-9
Chemical Name
ALPHA-AMANITIN
Synonyms
Α-AMANITIN;α-Amanitin;A-AMANITIN;Aids004473;α-Amatoxin;Aids-004473;AMANITIN, A-;ALPHA-AMANTIN;ALPHA-AMANITIN;alpha-amatoxin
CBNumber
CB3142945
Molecular Formula
C39H54N10O14S
Formula Weight
918.98
MOL File
23109-05-9.mol
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ALPHA-AMANITIN Property

Melting point:
254-255 °C(lit.)
alpha 
D20 +191°
Boiling point:
1622.2±65.0 °C(Predicted)
Density 
1.1626 (rough estimate)
refractive index 
1.7400 (estimate)
storage temp. 
−20°C
solubility 
H2O: 1.0 mg/mL
form 
powder
pka
9.63±0.70(Predicted)
color 
white to light yellow
optical activity
+19120 (H2O)
Water Solubility 
Soluble to 5 mM in ethanol and to 5 mM in water
Merck 
13,370
BRN 
1071138
InChIKey
CIORWBWIBBPXCG-PWKRRBCNNA-N
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-33-26/28
Safety Statements 
36/37/39-45-36/37-28
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
BD6195000
F 
8-10-18-21
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2934999090
Hazardous Substances Data
23109-05-9(Hazardous Substances Data)
Toxicity
LD50 i.p. in albino mice: 0.1 mg/kg (Wieland, Wieland)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A2263
Product name
α-Amanitin
Purity
from Amanita phalloides, ≥90% (HPLC), powder
Packaging
1mg
Price
$340
Updated
2024/03/01
Cayman Chemical
Product number
17898
Product name
α-Amanitin
Purity
≥90%
Packaging
1mg
Price
$227
Updated
2024/03/01
Tocris
Product number
4025
Product name
alpha-Amanitin
Purity
≥95%(HPLC)
Packaging
1
Price
$291
Updated
2021/12/16
Usbiological
Product number
257178
Product name
α-Amanitin
Packaging
1mg
Price
$588
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA57619
Product name
a-Amanitin
Packaging
5mg
Price
$800
Updated
2021/12/16
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ALPHA-AMANITIN Chemical Properties,Usage,Production

Uses

α-Amanitin has been used:

  • for inducing transcriptional arrest in NT2 cells prior to immunofluorescence assay
  • to induce nephrotoxicity in mice renal tissues
  • to induce and analyse genotoxicity in mice bone marrow cells by cell viability assay, comet assay and chromosomal aberration assay

Biological Activity

α-amanitin, the most deleterious toxin of a. phalloides to humans, inhibits rna polymerase ii (rnapii), causing hepatic and renal failure.

Biochem/physiol Actions

The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

storage

Store at -20°C

ALPHA-AMANITIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-AMANITIN Suppliers

China 71 Europe 2 Germany 4 India 1 Japan 2 Switzerland 3 United Kingdom 10 United States 15 Global 108
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
VWR International
Tel
--
Fax
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Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
Sequoia Research Products Ltd.
Tel
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Fax
--
Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
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View Lastest Price from ALPHA-AMANITIN manufacturers

Wuhan Boyuan Import & Export Co., LTD
Product
α-Amanitin 23109-05-9
Price
US $60.00-45.00/mg
Min. Order
1mg
Purity
99.96%
Supply Ability
1kg
Release date
2023-03-14
Hebei Kangcang new material Technology Co., LTD
Product
alpha-Amanitin 23109-05-9
Price
US $9.00-70.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 tons
Release date
2024-03-27
Hebei Fengqiang Trading Co., LTD
Product
α-Amanitin 23109-05-9
Price
US $100.00/drum
Min. Order
1drum
Purity
99
Supply Ability
5000
Release date
2023-09-05

23109-05-9, ALPHA-AMANITINRelated Search:

gamma-amanitin ALPHA-AMANITIN OLEATE alpha-Amanitin, 1-l-aspartic acid- METHYL ALPHA-AMANITIN OLEATE 6'-O-methyl alpha-amanitin 4,9-dioxo-5,10-diazatetradecane ALPHA-AMANITIN

  • Aids004473
  • Aids-004473
  • AMANITIN, a-(RG)
  • AMANITIN, a-(RG)(CALL)
  • cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide
  • alpha-AMantine, froM AManita Phalloides
  • Α-AMANITIN
  • AMANITIN, A-
  • ALPHA-AMANITIN
  • ALPHA-AMANITIN, AMANITA SPECIES
  • ALPHA-AMANITINE
  • A-AMANITIN
  • Cyclo[L-Asn-L-t4Hyp-[(3R,4R)-4,5-dihydroxy-3-methyl-L-Nva-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
  • alpha-amatoxin
  • cyclic(l-asparaginyl-4-hydroxy-l-prolyl-(r)-4,5-dihydroxy-l-isoleucyl-6-hydrox
  • ulfide,(r)-s-oxide
  • y-2-mercapto-l-tryptophylglycyl-l-isoleucylglycyl-l-cysteinyl),cyclic(4-8)-s
  • ALPHA-AMANITIN FROM AMANITA PHALLOIDES
  • A-AMANITIN FROM AMANITA PHALLOIDES
  • ALPHA-AMANTIN
  • ALPHA-AMANTINE
  • A-AMANTINE, FROM AMANITA PHALLOIDES
  • alpha-Amanitine, from Amanita Phalloides
  • Α-AMANITIN;Α-AMATOXIN
  • alpha-Amanitin (α-Amanitin
  • α-Amanitin DISCONTINUED
  • α-Amanitin, from Amanita Phalloides
  • α-Amanitin
  • α-Amatoxin
  • *Chlorobutanol Impurity?1 (Chlorobutanol EP Impurity?A)(Chloroform)
  • 23109-05-9
  • C39H54N10O14S
  • BioChemical
  • Biochemicals and Reagents
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors
  • DNA-RNA Transcription Regulators
  • Other
  • Alkaloids
  • DNA-RNA Transcription RegulatorsCell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Cell Signaling and Neuroscience
  • Mushroom
  • Toxins and Venoms
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Other
  • Miscellaneous Enzyme
  • inhibitor