4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane
- Product Name
- 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane
- CAS No.
- 57280-22-5
- Chemical Name
- 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane
- Synonyms
- 0]Octane;4-Dimethyl-3;8-trioxabic-yclo[5;Trioxabicyclooctane;4,4-dimethyl-3,5,8-;Gadobutrol Impurity 49;2-Ethoxyethyl ether 112-36-7;4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.]octane;4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane;3,5,8-Trioxabicyclo[5.1.0]octane, 4,4-diMethyl-
- CBNumber
- CB31452526
- Molecular Formula
- C7H12O3
- Formula Weight
- 144.17
- MOL File
- 57280-22-5.mol
4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Property
- Boiling point:
- 179℃
- Density
- 1.071
- refractive index
- 1.4560 to 1.4600
- Flash point:
- 56℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-43
- Safety Statements
- 26-36/37-24/25
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D5200
- Product name
- 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $30
- Updated
- 2024/03/01
- Product number
- D5200
- Product name
- 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $108
- Updated
- 2024/03/01
- Product number
- D480778
- Product name
- 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
- Packaging
- 25g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- FD29424
- Product name
- 4,4-Dimethyl-3,5,8-trioxabicyclo[5,1,0]octane
- Packaging
- 5G
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR302184
- Product name
- 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to yellow liquid
Uses
4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane is used in the CO2-mediated formation of chiral carbamates from meso-epoxides via polycarbonate intermediates and amine nucleophiles, which opens up a wide a wide range of CO2-based carbamate scaffolds with excellent yields and 99% enantiomeric excess.
Application
4, 4-dimethyl-3,5, 8-trioxane [5,1,0] octane is a key intermediate in the preparation of gadobinol. As a meso epoxide, it could be used to obtain optically pure ABT derivatives through Ti(IV)/BINOL catalyzed asymmetric aminolysis[1].
References
[1] Bao H, et al. Insight into the Mechanism of the Asymmetric Ring-Opening Aminolysis of 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane Catalyzed by Titanium/BINOLate/Water System: Evidence for the Ti(BINOLate)2-Bearing Active Catalyst Entities and the Role of Water. Journal of the American Chemical Society, 2008; 130: 10116–10127.
4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Preparation Products And Raw materials
Raw materials
Preparation Products
4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Suppliers
View Lastest Price from 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane manufacturers
- Product
- 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane 57280-22-5
- Price
- US $30.00-0.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-26
- Product
- 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]octane 57280-22-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 1-1000KGS
- Release date
- 2022-11-14
- Product
- 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane 57280-22-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27